Document Detail


Glutamic acid, GABA and their metabolising enzymes in the frog central nervous system.
MedLine Citation:
PMID:  1078986     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The regional distribution of 9 amino acids, including glutamate and GABA and their metabolising enzymes, has been determined in 5 regions of the frog CNS. Glycine was relatively concentrated in the spinal cord whereas the highest concentration of each of the other amino acids was found in the midbrain. There was a good correlation between the activity of l-glutamate-1-carboxylase (GAD) and the level of GABA in all regions examined and both were concentrated in the midbrain. There was little regional variation in the distribution of 4-aminobutyrate-2-oxoglutarate transaminase (GABA-T).
Authors:
R A Yates; P V Taberner
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Brain research     Volume:  84     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  1975 Feb 
Date Detail:
Created Date:  1975-06-27     Completed Date:  1975-06-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  399-407     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Amino Acids / metabolism*
Aminobutyric Acids / metabolism*
Animals
Brain / enzymology,  metabolism*
Carboxy-Lyases / metabolism*
Glutamates / metabolism*
Glycine / metabolism
Mesencephalon / metabolism
Rana temporaria
Spinal Cord / enzymology,  metabolism*
Transaminases / metabolism*
gamma-Aminobutyric Acid / metabolism*
Chemical
Reg. No./Substance:
0/Amino Acids; 0/Aminobutyric Acids; 0/Glutamates; 56-12-2/gamma-Aminobutyric Acid; 56-40-6/Glycine; EC 2.6.1.-/Transaminases; EC 4.1.1.-/Carboxy-Lyases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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