| Glutamatergic hyperfunctioning during alcohol withdrawal syndrome: Therapeutic perspective with zinc and magnesium. | |
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MedLine Citation:
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PMID: 21645973 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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It is known that the glutamatergic pathways are hyperfunctioning during alcohol withdrawal syndrome. It has been demonstrated that hyperfunctioning of this system causes a great damage to the superior cortical activity, the ability to concentrate and the control of impulses. Recent studies show that the cations zinc and magnesium modulate the glutamatergic function, reducing it to non-toxic levels, yet not reducing it to the point of depriving this neurotransmitter of its normal activity. New perspectives of treatment focus on the modulation of this system, having, as a result, reestablishment of impulse control abilities, damage prevention to the hippocampus and the amygdala and prevention of future relapses. |
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Authors:
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Pedro Luis Prior; José Carlos Fernandes Galduróz |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-6-4 |
Journal Detail:
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Title: Medical hypotheses Volume: - ISSN: 1532-2777 ISO Abbreviation: - Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-6-7 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7505668 Medline TA: Med Hypotheses Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Medicine, Federal University of São Paulo, Brazil. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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