Document Detail


Glutamatergic function in the resting awake human brain is supported by uniformly high oxidative energy.
MedLine Citation:
PMID:  23299240     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Rodent (13)C magnetic resonance spectroscopy studies show that glutamatergic signaling requires high oxidative energy in the awake resting state and allowed calibration of functional magnetic resonance imaging (fMRI) signal in terms of energy relative to the resting energy. Here, we derived energy used for glutamatergic signaling in the awake resting human. We analyzed human data of electroencephalography (EEG), positron emission tomography (PET) maps of oxygen (CMR(O2)) and glucose (CMR(glc)) utilization, and calibrated fMRI from a variety of experimental conditions. CMR(glc) and EEG in the visual cortex were tightly coupled over several conditions, showing that the oxidative demand for signaling was four times greater than the demand for nonsignaling events in the awake state. Variations of CMR(O2) and CMR(glc) from gray-matter regions and networks were within ±10% of means, suggesting that most areas required similar energy for ubiquitously high resting activity. Human calibrated fMRI results suggest that changes of fMRI signal in cognitive studies contribute at most ±10% CMR(O2) changes from rest. The PET data of sleep, vegetative state, and anesthesia show metabolic reductions from rest, uniformly >20% across, indicating no region is selectively reduced when consciousness is lost. Future clinical investigations will benefit from using quantitative metabolic measures.
Authors:
Fahmeed Hyder; Robert K Fulbright; Robert G Shulman; Douglas L Rothman
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2013-01-09
Journal Detail:
Title:  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism     Volume:  33     ISSN:  1559-7016     ISO Abbreviation:  J. Cereb. Blood Flow Metab.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-03-01     Completed Date:  2013-04-19     Revised Date:  2014-03-17    
Medline Journal Info:
Nlm Unique ID:  8112566     Medline TA:  J Cereb Blood Flow Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  339-47     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Cognition / physiology
Electroencephalography
Energy Metabolism / physiology*
Female
Glutamine / metabolism*
Humans
Magnetic Resonance Imaging / methods*
Male
Positron-Emission Tomography / methods*
Rodentia
Visual Cortex / physiology*
Wakefulness / physiology*
Grant Support
ID/Acronym/Agency:
P30 NS-052519/NS/NINDS NIH HHS; R01 AG-034953/AG/NIA NIH HHS; R01 AG034953/AG/NIA NIH HHS; R01 MH-067528/MH/NIMH NIH HHS; R01 MH067528/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
0RH81L854J/Glutamine
Comments/Corrections
Erratum In:
J Cereb Blood Flow Metab. 2014 Feb;34(2):368

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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