| Glutamatergic compensatory mechanisms in experimental parkinsonism. | |
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MedLine Citation:
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PMID: 9682276 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1. Injection cannulae allowing access to the SNc were implanted bilaterally in four monkeys. Once animals had recovered from the operation, daily low-dose treatment with MPTP was started. 2. Group I comprised two monkeys under treatment with MPTP, but still asymptomatic. Group II comprised two monkeys treated with MPTP and presenting clinical symptoms. 3. Both groups received daily intracranial injections of kynurenic acid in order to block the glutamatergic afferents to the SNc. 4. In the first group of asymptomatic monkeys, kynurenic acid induced parkinsonian motor abnormalities. In the second group of symptomatic monkeys, it increased the severity of clinical signs. 5. Glutamatergic inputs to the SNc would therefore appear to be implicated in compensatory phenomena at different stages of experimental parkinsonism. |
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Authors:
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E Bezard; B Bioulac; C E Gross |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Progress in neuro-psychopharmacology & biological psychiatry Volume: 22 ISSN: 0278-5846 ISO Abbreviation: Prog. Neuropsychopharmacol. Biol. Psychiatry Publication Date: 1998 May |
Date Detail:
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Created Date: 1998-10-13 Completed Date: 1998-10-13 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8211617 Medline TA: Prog Neuropsychopharmacol Biol Psychiatry Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 609-23 Citation Subset: IM |
Affiliation:
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Laboratoire de Neurophysiologie, CNRS UMR 5543, Université de Bordeaux II, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
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administration & dosage Animals Dopamine Agonists / administration & dosage Kynurenic Acid Macaca fascicularis Motor Activity / physiology Parkinson Disease, Secondary / chemically induced*, physiopathology Receptors, Glutamate / physiology* Substantia Nigra / physiopathology* |
| Chemical | |
Reg. No./Substance:
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0/Dopamine Agonists; 0/Receptors, Glutamate; 28289-54-5/1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 492-27-3/Kynurenic Acid |
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