Document Detail

Glutamatergic compensatory mechanisms in experimental parkinsonism.
MedLine Citation:
PMID:  9682276     Owner:  NLM     Status:  MEDLINE    
1. Injection cannulae allowing access to the SNc were implanted bilaterally in four monkeys. Once animals had recovered from the operation, daily low-dose treatment with MPTP was started. 2. Group I comprised two monkeys under treatment with MPTP, but still asymptomatic. Group II comprised two monkeys treated with MPTP and presenting clinical symptoms. 3. Both groups received daily intracranial injections of kynurenic acid in order to block the glutamatergic afferents to the SNc. 4. In the first group of asymptomatic monkeys, kynurenic acid induced parkinsonian motor abnormalities. In the second group of symptomatic monkeys, it increased the severity of clinical signs. 5. Glutamatergic inputs to the SNc would therefore appear to be implicated in compensatory phenomena at different stages of experimental parkinsonism.
E Bezard; B Bioulac; C E Gross
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Progress in neuro-psychopharmacology & biological psychiatry     Volume:  22     ISSN:  0278-5846     ISO Abbreviation:  Prog. Neuropsychopharmacol. Biol. Psychiatry     Publication Date:  1998 May 
Date Detail:
Created Date:  1998-10-13     Completed Date:  1998-10-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8211617     Medline TA:  Prog Neuropsychopharmacol Biol Psychiatry     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  609-23     Citation Subset:  IM    
Laboratoire de Neurophysiologie, CNRS UMR 5543, Université de Bordeaux II, France.
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MeSH Terms
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine / administration & dosage
Dopamine Agonists / administration & dosage
Kynurenic Acid
Macaca fascicularis
Motor Activity / physiology
Parkinson Disease, Secondary / chemically induced*,  physiopathology
Receptors, Glutamate / physiology*
Substantia Nigra / physiopathology*
Reg. No./Substance:
0/Dopamine Agonists; 0/Receptors, Glutamate; 28289-54-5/1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 492-27-3/Kynurenic Acid

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