| Glutamate uptake into synaptic vesicles--inhibition by sulphur amino acids. | |
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MedLine Citation:
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PMID: 1680485 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In an attempt to investigate the apparent absolute selectivity of the synaptic vesicle L-glutamate carrier, L- and D-enantiomers of excitatory sulphur-containing amino acid (SAA) transmitter candidates (which are close structural analogues of L-glutamate) were tested for their capacity to compete for vesicular L-[3H]-glutamate uptake. All SAAs inhibited, to varying degrees (52-86%), the vesicular uptake of L-[3H]-glutamate. A similar level of inhibition was exerted by SAAs with either a shorter or equal carbon chain length to L-glutamate. Moreover, inhibition was stereospecific in favour of the D-enantiomers. These studies indicate an appreciable interaction of the SAAs with the recognition site of the vesicular L-glutamate carrier. Further investigations are required to establish the substrate potential of the SAAs. |
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Authors:
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J Dunlop; A Fear; R Griffiths |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Neuroreport Volume: 2 ISSN: 0959-4965 ISO Abbreviation: Neuroreport Publication Date: 1991 Jul |
Date Detail:
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Created Date: 1991-10-30 Completed Date: 1991-10-30 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9100935 Medline TA: Neuroreport Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 377-9 Citation Subset: IM |
Affiliation:
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Department of Biochemistry and Microbiology, University of St. Andrews, Fife, Scotland, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biological Transport / drug effects Cerebral Cortex / metabolism* Cysteine / analogs & derivatives*, pharmacology* Glutamates / metabolism* Glutamic Acid Homocysteine / analogs & derivatives, pharmacology* Kinetics Male Neurotransmitter Agents / pharmacology* Rats Rats, Inbred Strains Stereoisomerism Structure-Activity Relationship Synaptic Vesicles / drug effects, metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Glutamates; 0/Neurotransmitter Agents; 454-28-4/Homocysteine; 52-90-4/Cysteine; 56-86-0/Glutamic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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