Document Detail


Glutamate uptake into synaptic vesicles--inhibition by sulphur amino acids.
MedLine Citation:
PMID:  1680485     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In an attempt to investigate the apparent absolute selectivity of the synaptic vesicle L-glutamate carrier, L- and D-enantiomers of excitatory sulphur-containing amino acid (SAA) transmitter candidates (which are close structural analogues of L-glutamate) were tested for their capacity to compete for vesicular L-[3H]-glutamate uptake. All SAAs inhibited, to varying degrees (52-86%), the vesicular uptake of L-[3H]-glutamate. A similar level of inhibition was exerted by SAAs with either a shorter or equal carbon chain length to L-glutamate. Moreover, inhibition was stereospecific in favour of the D-enantiomers. These studies indicate an appreciable interaction of the SAAs with the recognition site of the vesicular L-glutamate carrier. Further investigations are required to establish the substrate potential of the SAAs.
Authors:
J Dunlop; A Fear; R Griffiths
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neuroreport     Volume:  2     ISSN:  0959-4965     ISO Abbreviation:  Neuroreport     Publication Date:  1991 Jul 
Date Detail:
Created Date:  1991-10-30     Completed Date:  1991-10-30     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  9100935     Medline TA:  Neuroreport     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  377-9     Citation Subset:  IM    
Affiliation:
Department of Biochemistry and Microbiology, University of St. Andrews, Fife, Scotland, UK.
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MeSH Terms
Descriptor/Qualifier:
Animals
Biological Transport / drug effects
Cerebral Cortex / metabolism*
Cysteine / analogs & derivatives*,  pharmacology*
Glutamates / metabolism*
Glutamic Acid
Homocysteine / analogs & derivatives,  pharmacology*
Kinetics
Male
Neurotransmitter Agents / pharmacology*
Rats
Rats, Inbred Strains
Stereoisomerism
Structure-Activity Relationship
Synaptic Vesicles / drug effects,  metabolism*
Chemical
Reg. No./Substance:
0/Glutamates; 0/Neurotransmitter Agents; 454-28-4/Homocysteine; 52-90-4/Cysteine; 56-86-0/Glutamic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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