Document Detail


Glutamate inhibition in MS: the neuroprotective properties of riluzole.
MedLine Citation:
PMID:  15949499     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In addition to demyelination and damage to oligodendrocytes, axonal injury and neuronal cell death are dominating histopathological characteristics of multiple sclerosis (MS). Still little is known about the cause of the damage. Extracellular accumulation of glutamate contributes to excitotoxic injury of neurons and glial cells, suggesting that the maintenance of subtoxic extracellular glutamate levels may be crucial. Riluzole is a neuroprotective agent that inhibits the release of glutamate from nerve terminals and modulates glutamate, i.e., kainate and NMDA receptors. It inhibits excitotoxic injury in several experimental models of neurodegenerative disease. We performed a small run-in versus treatment MR-monitored pilot study in 16 primary progressive MS patients. The results suggest that riluzole reduces the rate of cervical cord atrophy and the development of T1 hypointense lesions on magnetic resonance imaging in primary progressive MS. The rate of brain atrophy was only slightly decreased. The results indicate an effect on mechanisms involving lesion evolution and axonal loss, but no clear effect on new lesion formation. However, the data suffer from several limitations and must be confirmed in future trials.
Authors:
Joep Killestein; Nynke F Kalkers; Chris H Polman
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article     Date:  2005-04-20
Journal Detail:
Title:  Journal of the neurological sciences     Volume:  233     ISSN:  0022-510X     ISO Abbreviation:  J. Neurol. Sci.     Publication Date:  2005 Jun 
Date Detail:
Created Date:  2005-06-13     Completed Date:  2005-08-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375403     Medline TA:  J Neurol Sci     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  113-5     Citation Subset:  IM    
Affiliation:
Department of Neurology, VU Medical Centre, P.O. Box 7057, 1007 MB, Amsterdam, The Netherlands. J.Killestein@vumc.nl
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Female
Follow-Up Studies
Glutamic Acid / metabolism*
Humans
Magnetic Resonance Imaging / methods
Male
Middle Aged
Multiple Sclerosis / drug therapy*,  metabolism,  pathology
Neuroprotective Agents / therapeutic use*
Riluzole / therapeutic use*
Spinal Cord / pathology
Chemical
Reg. No./Substance:
0/Neuroprotective Agents; 1744-22-5/Riluzole; 56-86-0/Glutamic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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