| Glutamate in opioid dependence. | |
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MedLine Citation:
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PMID: 9365966 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The present review will concentrate on a discussion of recent investigations which implicate a critical linkage of three facets of the central nervous system mediation of opioid dependence, as evidenced by expression of acutely-precipitated withdrawal events. These are the kappa-opioid receptor subtype, the glutamatergic neuronal system and a specific brain locus, the locus coeruleus. The impetus for this line of investigation derives from a recognition that opioid analgesics, such as butorphanol (Stadol), exhibit a markedly different profile of activity at opioid receptors than does morphine yet have abuse liability and cause dependence readily. Emphasis will be placed on demonstration of a rodent model in which butorphanol administration induces dependence through a unique (in comparison with morphine) activation of the kappa-opioid receptor. The use of in vivo microdialysis techniques clearly identifies, in this model, that acutely-precipitated withdrawal from dependence on butorphanol results in focal increases in extracellular levels of glutamate within the locus coeruleus, and that the withdrawal syndrome can be mimicked by intracerebroventricular administration of exogenous glutamate, acting through the N-methyl-D-aspartate glutamate receptor subtype. The data confirm the participation of glutamate as a general phenomenon in opioid dependence, identify the locus coeruleus as a primary site for glutamatergic mediation of dependence, and suggest novel aspects to the neuropharmacology of opioid dependence with respect to the role of the kappa-opioid receptor. |
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Authors:
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I K Ho; Y Z Feng; S Tokuyama; K Hoshi; R W Rockhold |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology Volume: 17 ISSN: 1340-2544 ISO Abbreviation: Nihon Shinkei Seishin Yakurigaku Zasshi Publication Date: 1997 Aug |
Date Detail:
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Created Date: 1998-01-09 Completed Date: 1998-01-09 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9509023 Medline TA: Nihon Shinkei Seishin Yakurigaku Zasshi Country: JAPAN |
Other Details:
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Languages: eng Pagination: 175-80 Citation Subset: IM |
Affiliation:
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Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson 39216-4505, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Analgesics, Opioid Animals Butorphanol Glutamic Acid / physiology* Locus Coeruleus / physiology Microdialysis Opioid-Related Disorders* Rats Receptors, Opioid, kappa / physiology Substance Withdrawal Syndrome |
| Grant Support | |
ID/Acronym/Agency:
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DA-05828/DA/NIDA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Analgesics, Opioid; 0/Receptors, Opioid, kappa; 42408-82-2/Butorphanol; 56-86-0/Glutamic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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