Document Detail


Glutamate decarboxylase-67 messenger RNA expression in normal human basal ganglia and in Parkinson's disease.
MedLine Citation:
PMID:  8931005     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Expression of glutamate decarboxylase-67 messenger RNA was examined in the basal ganglia of normal controls and of cases of Parkinson's disease using in situ hybridization histochemistry in human post mortem material. In controls glutamate decarboxylase-67 messenger RNA expression was detected in all large neurons in both segments of the globus pallidus and in three neuronal subpopulations in the striatum as well as in substantia nigra reticulata neurons and in a small sub-population of subthalamic neurons. In Parkinson's disease, there was a statistically significant decrease of 50.7% in glutamate decarboxylase-67 messenger RNA expression per neuron in the lateral segment of the globus pallidus (controls: mean 72.8 microns2 +/- S.E.M. 8.7 of silver grain/neuron, n = 12; Parkinson's disease: mean 35.9 microns2 +/- S.E.M. 9.7 of silver grain/neuron, n = 9, P = 0.01, Student's t-test). In the medial segment of the globus pallidus, there was a small, but non-significant decrease of glutamate decarboxylase-67 messenger RNA expression in Parkinson's disease (controls: mean 100.6 microns2 +/- S.E.M. 7.2 of silver grain/neuron, n = 11; Parkinson's disease: mean 84.8 microns2 +/- S.E.M. 13.0 of silver grain/neuron, n = 7, P = 0.1, Student's t-test). No significant differences in glutamate decarboxylase-67 messenger RNA were detected in striatal neuronal sub-populations between Parkinson's disease cases and controls. These results are the first direct evidence in humans that there is increased inhibitory drive to the lateral segment of the globus pallidus in Parkinson's disease, as suggested by data from animal models. We therefore provide theoretical support for current experimental neurosurgical approaches to Parkinson's disease.
Authors:
A P Nisbet; D J Eve; A E Kingsbury; S E Daniel; C D Marsden; A J Lees; O J Foster
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuroscience     Volume:  75     ISSN:  0306-4522     ISO Abbreviation:  Neuroscience     Publication Date:  1996 Nov 
Date Detail:
Created Date:  1997-03-14     Completed Date:  1997-03-14     Revised Date:  2009-09-29    
Medline Journal Info:
Nlm Unique ID:  7605074     Medline TA:  Neuroscience     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  389-406     Citation Subset:  IM    
Affiliation:
Parkinson's Disease Society Brain Bank, London, U.K.
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Basal Ganglia / enzymology*,  pathology
Blotting, Northern
DNA Probes
Female
Globus Pallidus / metabolism,  pathology
Glutamate Decarboxylase / biosynthesis*
Humans
In Situ Hybridization
Male
Middle Aged
Parkinson Disease / enzymology*,  pathology
Putamen / metabolism,  pathology
RNA, Messenger / biosynthesis*
Substantia Nigra / metabolism,  pathology
Thalamic Nuclei / metabolism,  pathology
Grant Support
ID/Acronym/Agency:
//Wellcome Trust
Chemical
Reg. No./Substance:
0/DNA Probes; 0/RNA, Messenger; EC 4.1.1.15/Glutamate Decarboxylase

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