Document Detail


Glutamate antagonists in rat hippocampus.
MedLine Citation:
PMID:  990589     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1 Hippocampal cellular responses to acidic amino acids and some of their antagonists were measured in the rat anaesthetized with urethane. The effects of these antagonists of the field responses of the rat hippocampus to afferent stimulation were measured in acute as well as chronically prepared rats. 2. Hippocampal pyramidal cells were excited by microiontophoretic application of glutamate and aspartate. These responses were antagonized by glutamic acid diethyl ester (GDEE), glutamic acid dimethyl ester (GDME) and by proline. Partial specificity could be seen as excitatory responses to acetylcholine were less susceptible to the antagonists. 3 field responses of the hippocampus to commissural stimulation were reduced significantly in both an acutely prepared or the conscious rat following parenteral administration of GDEE and GDME but not proline. Responses to perforant path stimulation were not affected by these drugs. 4 It is suggested that an acidic amino acid may serve as a neurotransmitter in the commissural path to-area CA1 of the dorsal hippocampus.
Authors:
M Segal
Related Documents :
7907219 - Effect of phencyclidine on endogenous excitatory amino acid release from the rat anteri...
2898959 - Quinolinic acid effects on amino acid release from the rat cerebral cortex in vitro and...
1720099 - Thiokynurenates: a new group of antagonists of the glycine modulatory site of the nmda ...
9681959 - Kainic acid induction of heme oxygenase in vivo and in vitro.
15883359 - Noncholinergic excitatory actions of motoneurons in the neonatal mammalian spinal cord.
22393259 - Spatiotemporal localization of d-amino acid oxidase and d-aspartate oxidases during the...
23545469 - Seasonal upregulation of catabolic enzymes and fatty acid transporters in the flight mu...
7858939 - Ecdysteroid titre and metabolism and cuticle deposition during embryogenesis of the ixo...
4780689 - The irreversible disposal rate of free fatty acids in the plasma of fed and starved rats.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British journal of pharmacology     Volume:  58     ISSN:  0007-1188     ISO Abbreviation:  Br. J. Pharmacol.     Publication Date:  1976 Nov 
Date Detail:
Created Date:  1977-01-29     Completed Date:  1977-01-29     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7502536     Medline TA:  Br J Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  341-5     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Acetylcholine / pharmacology
Action Potentials / drug effects
Animals
Evoked Potentials / drug effects
Glutamates / antagonists & inhibitors*
Hippocampus / physiology*
Male
Proline / pharmacology
Rats
Tissue Extracts / pharmacology*
Chemical
Reg. No./Substance:
0/Glutamates; 0/Tissue Extracts; 147-85-3/Proline; 51-84-3/Acetylcholine
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Prostaglandin antagonism by sodium p-benzyl-4-[1-oxo-2-(4-chlorobenzyl)-3-phenylpropyl]pheenyl phosp...
Next Document:  Anaesthetics depress the sensitivity of cortical neurones to L-glutamate.