Document Detail

Glue embolization for endoscopically unmanageable gastrointestinal haemorrhage.
MedLine Citation:
PMID:  22057378     Owner:  NLM     Status:  MEDLINE    
BACKGROUND/AIMS: To evaluate the clinical feasibility of embolization with n-butyl cyanoacrylate (NBCA) for endoscopically unmanageable non-variceal gastrointestinal hemorrhage (GIH).
METHODOLOGY: Between June 2004 and May 2009, 61 patients with confirmed acute upper and/or lower GIH underwent emergency embolization for haemorrhage control; NBCA was used in 28 of these patients, all of whom were in shock despite receiving blood transfusions. The results were studied retrospectively. Clinical parameters and embolization data were assessed for technical success, clinical success and outcome.
RESULTS: Technical success was achieved in all patients. Clinical success was achieved in 19 (68%) of the 28 patients. The mortality rate was 25% (7 patients). The cause of death was disseminated intravascular coagulation (DIC) in 6 patients and heart failure in 1. The presence of coagulopathy or DIC significantly decreased the degree of clinical success (p=0.015, p=0.001, respectively) and increased the mortality rate (p=0.013, p<0.001, respectively). Unfortunately, 86% patients who had DIC before embolization, died.
CONCLUSIONS: NBCA embolization is technically feasible and is effective for the control of haemorrhage in endoscopically unmanageable GIH. However, the presence of coagulopathy or DIC significantly decreases the clinical success and increases the mortality rate.
Satoru Murata; Shiro Onozawa; Ken Nakazawa; Takahiko Mine; Tatsuo Ueda; Hiroyuki Tajima; Hiroshi Yoshida; Shinichiro Kumita
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Hepato-gastroenterology     Volume:  59     ISSN:  0172-6390     ISO Abbreviation:  Hepatogastroenterology     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-05-14     Completed Date:  2012-07-31     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  8007849     Medline TA:  Hepatogastroenterology     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  1126-30     Citation Subset:  IM    
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MeSH Terms
Aged, 80 and over
Embolization, Therapeutic / methods*
Enbucrilate / therapeutic use*
Gastrointestinal Hemorrhage / blood,  mortality,  therapy*
Middle Aged
Retrospective Studies
Tissue Adhesives / therapeutic use*
Reg. No./Substance:
0/Tissue Adhesives; F8CEP82QNP/Enbucrilate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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