Document Detail

Glucuronic acid and phosphoserine act as mineralization mediators of collagen I based biomimetic substrates.
MedLine Citation:
PMID:  19941043     Owner:  NLM     Status:  MEDLINE    
Glucuronic acid (GlcA) and phosphoserine (pS) carrying acidic functional groups were used as model molecules for glycosaminoglycans and phosphoproteins, respectively to mimic effects of native biomolecules and influence the mineralization behaviour of collagen I. Collagen substrates modified with GlcA showed a stable interaction between GlcA and collagen fibrils. Substrates were mineralized using the electrochemically assisted deposition (ECAD) in a Ca(2+)/H( x )PO (4) ((3-x)) electrolyte at physiological pH and temperature. During mineralization of collagen-GlcA matrices, crystalline hydroxyapatite (HA) formed earlier with increasing GlcA content of the collagen matrix, while the addition of pS to the electrolyte succeeded in inhibiting the transformation of preformed amorphous calcium phosphate (ACP) to HA. The lower density of the resulting mineralization and the coalesced aggregates formed at a certain pS concentration suggest an interaction between calcium and the phosphate groups of pS involving the formation of complexes. Combining GlcA-modified collagen and pS-modified electrolyte showed dose-dependent cooperative effects.
Ricardo Tejero; Susanne Bierbaum; Timothy Douglas; Antje Reinstorf; Hartmut Worch; Dieter Scharnweber
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Publication Detail:
Type:  Journal Article     Date:  2009-11-26
Journal Detail:
Title:  Journal of materials science. Materials in medicine     Volume:  21     ISSN:  1573-4838     ISO Abbreviation:  J Mater Sci Mater Med     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-02-11     Completed Date:  2010-05-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9013087     Medline TA:  J Mater Sci Mater Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  407-18     Citation Subset:  IM    
Max Bergmann Center of Biomaterials, Dresden University of Technology, Budapester Str. 27, 01069, Dresden, Germany.
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MeSH Terms
Biomimetic Materials / chemistry*
Body Fluids / chemistry*
Bone Substitutes / chemistry*
Collagen Type I / chemistry*
Crystallization / methods
Glucuronic Acid / chemistry*
Materials Testing
Minerals / chemistry*
Phosphoserine / chemistry*
Reg. No./Substance:
0/Bone Substitutes; 0/Collagen Type I; 0/Minerals; 17885-08-4/Phosphoserine; 576-37-4/Glucuronic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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