Document Detail


Glucosylceramide in humans.
MedLine Citation:
PMID:  20919653     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Glucosylceramide has a unique and often ambiguous role in mammalian cells. Activation of glucosylceramide synthase, the enzyme that places a glucosyl moiety onto ceramide, is the first pathway-committed step to the production of more complex glycosphingolipids such as lactosylceramide and gangliosides. Alterations in the level of glucosylceramide are noted in cells and tissues in response to cardiovascular disease, diabetes, skin disorders and cancer. Overall, upregulation of glucosylceramide offers cellular protection and primes certain cells for proliferation. However, prolonged overabundance of glucosylceramide is detrimental, as seen in Gaucher disease in humans.
Authors:
Maria C Messner; Myles C Cabot
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Advances in experimental medicine and biology     Volume:  688     ISSN:  0065-2598     ISO Abbreviation:  Adv. Exp. Med. Biol.     Publication Date:  2010  
Date Detail:
Created Date:  2010-10-05     Completed Date:  2010-11-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0121103     Medline TA:  Adv Exp Med Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  156-64     Citation Subset:  IM    
Affiliation:
John Wayne Cancer Institute, 2200 Santa Monica Blvd, Santa Monica, California 90404, USA.
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MeSH Terms
Descriptor/Qualifier:
Brain / metabolism
Cardiovascular System / metabolism
Glucosylceramides / chemistry,  metabolism*
Humans
Immune System / metabolism
Membrane Microdomains / metabolism
Models, Biological
Neoplasms / metabolism
Skin / metabolism
Grant Support
ID/Acronym/Agency:
GM77391/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Glucosylceramides

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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