| Glucosylceramide in humans. | |
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MedLine Citation:
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PMID: 20919653 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Glucosylceramide has a unique and often ambiguous role in mammalian cells. Activation of glucosylceramide synthase, the enzyme that places a glucosyl moiety onto ceramide, is the first pathway-committed step to the production of more complex glycosphingolipids such as lactosylceramide and gangliosides. Alterations in the level of glucosylceramide are noted in cells and tissues in response to cardiovascular disease, diabetes, skin disorders and cancer. Overall, upregulation of glucosylceramide offers cellular protection and primes certain cells for proliferation. However, prolonged overabundance of glucosylceramide is detrimental, as seen in Gaucher disease in humans. |
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Authors:
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Maria C Messner; Myles C Cabot |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Advances in experimental medicine and biology Volume: 688 ISSN: 0065-2598 ISO Abbreviation: Adv. Exp. Med. Biol. Publication Date: 2010 |
Date Detail:
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Created Date: 2010-10-05 Completed Date: 2010-11-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0121103 Medline TA: Adv Exp Med Biol Country: United States |
Other Details:
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Languages: eng Pagination: 156-64 Citation Subset: IM |
Affiliation:
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John Wayne Cancer Institute, 2200 Santa Monica Blvd, Santa Monica, California 90404, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Brain
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metabolism Cardiovascular System / metabolism Glucosylceramides / chemistry, metabolism* Humans Immune System / metabolism Membrane Microdomains / metabolism Models, Biological Neoplasms / metabolism Skin / metabolism |
| Grant Support | |
ID/Acronym/Agency:
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GM77391/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Glucosylceramides |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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