| Glucosylated deferiprone and its brain uptake: implications for developing glucosylated hydroxypyridinone analogues intended to cross the blood-brain barrier. | |
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MedLine Citation:
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PMID: 20684616 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This report presents that Deferiprone, the only clinically used 3-hydroxypyridin-4-one (HPO), is able to penetrate the blood-brain barrier (BBB) in guinea pigs, whereas its glucosylated analogue is unable to do so. This finding is contrary to published information suggesting that the glucosylation of HPOs is a viable means of enhancing the brain uptake of this group of compounds. |
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Authors:
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Sourav Roy; Jane E Preston; Robert C Hider; Yong Min Ma |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of medicinal chemistry Volume: 53 ISSN: 1520-4804 ISO Abbreviation: J. Med. Chem. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-08-05 Completed Date: 2010-09-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9716531 Medline TA: J Med Chem Country: United States |
Other Details:
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Languages: eng Pagination: 5886-9 Citation Subset: IM |
Affiliation:
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Pharmaceutical Science Division, King's College London, London, UK. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood-Brain Barrier / metabolism* Glycosylation Guinea Pigs Iron Chelating Agents / pharmacokinetics* Male Pyridones / pharmacokinetics* Rats Tissue Distribution |
| Chemical | |
Reg. No./Substance:
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0/Iron Chelating Agents; 0/Pyridones; 30652-11-0/deferiprone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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