Document Detail


Glucosylated deferiprone and its brain uptake: implications for developing glucosylated hydroxypyridinone analogues intended to cross the blood-brain barrier.
MedLine Citation:
PMID:  20684616     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This report presents that Deferiprone, the only clinically used 3-hydroxypyridin-4-one (HPO), is able to penetrate the blood-brain barrier (BBB) in guinea pigs, whereas its glucosylated analogue is unable to do so. This finding is contrary to published information suggesting that the glucosylation of HPOs is a viable means of enhancing the brain uptake of this group of compounds.
Authors:
Sourav Roy; Jane E Preston; Robert C Hider; Yong Min Ma
Related Documents :
12220696 - Activation of the tissue kallikrein-kinin system in stroke.
2398356 - Permeability of the blood-brain barrier to the immunosuppressive cyclic peptide cyclosp...
15554426 - Blood ammonia levels and hepatic encephalopathy.
592296 - The blood-testis barrier and temperature damage to the testis of the rat.
10846776 - Fetal cerebral blood flow redistribution in late gestation: identification of compromis...
6683646 - Hypothermic perfusion of human kidney carcinoma: effects on viability and perfusate dis...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of medicinal chemistry     Volume:  53     ISSN:  1520-4804     ISO Abbreviation:  J. Med. Chem.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-08-05     Completed Date:  2010-09-08     Revised Date:  2013-06-03    
Medline Journal Info:
Nlm Unique ID:  9716531     Medline TA:  J Med Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  5886-9     Citation Subset:  IM    
Affiliation:
Pharmaceutical Science Division, King's College London, London, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Blood-Brain Barrier / metabolism*
Glycosylation
Guinea Pigs
Iron Chelating Agents / pharmacokinetics*
Male
Pyridones / pharmacokinetics*
Rats
Tissue Distribution
Chemical
Reg. No./Substance:
0/Iron Chelating Agents; 0/Pyridones; 2BTY8KH53L/deferiprone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Synthesis and Resolution of cis-(+/-)-Methyl (1R,2S/1S,2R)-2-[(4-Hydroxy-4-phenylpiperidin-1-yl)meth...
Next Document:  A solution study of silica condensation and speciation with relevance to in vitro investigations of ...