Document Detail

Glucosylated deferiprone and its brain uptake: implications for developing glucosylated hydroxypyridinone analogues intended to cross the blood-brain barrier.
MedLine Citation:
PMID:  20684616     Owner:  NLM     Status:  MEDLINE    
This report presents that Deferiprone, the only clinically used 3-hydroxypyridin-4-one (HPO), is able to penetrate the blood-brain barrier (BBB) in guinea pigs, whereas its glucosylated analogue is unable to do so. This finding is contrary to published information suggesting that the glucosylation of HPOs is a viable means of enhancing the brain uptake of this group of compounds.
Sourav Roy; Jane E Preston; Robert C Hider; Yong Min Ma
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of medicinal chemistry     Volume:  53     ISSN:  1520-4804     ISO Abbreviation:  J. Med. Chem.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-08-05     Completed Date:  2010-09-08     Revised Date:  2013-06-03    
Medline Journal Info:
Nlm Unique ID:  9716531     Medline TA:  J Med Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  5886-9     Citation Subset:  IM    
Pharmaceutical Science Division, King's College London, London, UK.
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MeSH Terms
Blood-Brain Barrier / metabolism*
Guinea Pigs
Iron Chelating Agents / pharmacokinetics*
Pyridones / pharmacokinetics*
Tissue Distribution
Reg. No./Substance:
0/Iron Chelating Agents; 0/Pyridones; 2BTY8KH53L/deferiprone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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