| Glucose transporters in the 21st Century. | |
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MedLine Citation:
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PMID: 20009031 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The ability to take up and metabolize glucose at the cellular level is a property shared by the vast majority of existing organisms. Most mammalian cells import glucose by a process of facilitative diffusion mediated by members of the Glut (SLC2A) family of membrane transport proteins. Fourteen Glut proteins are expressed in the human and they include transporters for substrates other than glucose, including fructose, myoinositol, and urate. The primary physiological substrates for at least half of the 14 Glut proteins are either uncertain or unknown. The well-established glucose transporter isoforms, Gluts 1-4, are known to have distinct regulatory and/or kinetic properties that reflect their specific roles in cellular and whole body glucose homeostasis. Separate review articles on many of the Glut proteins have recently appeared in this journal. Here, we provide a very brief summary of the known properties of the 14 Glut proteins and suggest some avenues of future investigation in this area. |
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Authors:
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Bernard Thorens; Mike Mueckler |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review Date: 2009-12-15 |
Journal Detail:
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Title: American journal of physiology. Endocrinology and metabolism Volume: 298 ISSN: 1522-1555 ISO Abbreviation: Am. J. Physiol. Endocrinol. Metab. Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-08-17 Completed Date: 2010-09-01 Revised Date: 2011-07-22 |
Medline Journal Info:
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Nlm Unique ID: 100901226 Medline TA: Am J Physiol Endocrinol Metab Country: United States |
Other Details:
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Languages: eng Pagination: E141-5 Citation Subset: IM |
Affiliation:
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Department of Physiology and Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Glucose
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metabolism* Glucose Transport Proteins, Facilitative / classification, metabolism* Humans Membrane Transport Proteins / classification, metabolism |
| Grant Support | |
ID/Acronym/Agency:
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R0143695//PHS HHS |
| Chemical | |
Reg. No./Substance:
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0/Glucose Transport Proteins, Facilitative; 0/Membrane Transport Proteins; 50-99-7/Glucose |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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