| Glucose transporter 1 expression, tumor proliferation, and iodine/glucose uptake in thyroid cancer with emphasis on poorly differentiated thyroid carcinoma. | |
| | |
MedLine Citation:
|
PMID: 22228332 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
PURPOSE: : Glucose transporters 1 (GLUT1) facilitates glucose uptake in cancer. An inverse relationship between I-131 and F-18 fluorodeoxyglucose (FDG) uptake in PET/CT ("flip-flop phenomenon") was described for thyroid cancers (TCs) during dedifferentiation. We investigated the relationship among GLUT1 expression, proliferation, iodine concentration, and glucose uptake in different TC types, with emphasis on "poorly differentiated thyroid carcinoma" (PDTC). METHODS: : For immunohistochemistry, 95 thyroid tumors (follicular adenoma, papillary TC, follicular TC, PDTC, and anaplastic TC [ATC]) were investigated for GLUT1 expression and proliferation (Ki-67 index). For PET/CT study, 47 F-18 FDG PET/CT of patients with TC (22 PDTC), 39 corresponding I-124 PET/CT, and glucose and iodine uptake were evaluated. PTC and FTC were summarized under differentiated TC (DTC). RESULTS: : Immunohistochemistry: 65% of TC expressed GLUT1. The number of GLUT1-positive TC and GLUT1 expression increased with escalating dedifferentiation/aggressiveness of TC types (P < 0.001). A correlation between proliferation and GLUT1 expression was noted (P < 0.001). PET/CT study: F-18 FDG uptake was measured in 81% of cases. Occurrence of F-18 FDG-avid cases as well as median F-18 FDG maximum standardized uptake values were lowest in DTC, intermediate in PDTC, and highest in ATC. Accordingly, numbers of iodine-avid cases and median I-124 maximum standardized uptake value featured an inverse pattern. CONCLUSIONS: : Dedifferentiation in TC is accompanied by GLUT1 upregulation and increased proliferation. PDTC was found to be intermediate between DTC and ATC in terms of GLUT1 expression and F-18 FDG or I-124 uptake, suggesting that the flip-flop phenomenon occurs at a dedifferentiation stage in between. Furthermore, the results suggest that F-18 FDG PET/CT is an important imaging modality for ATC and PDTC. |
| | |
Authors:
|
Florian Grabellus; James Nagarajah; Andreas Bockisch; Schmid Kurt Werner; Sien-Yi Sheu |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Clinical nuclear medicine Volume: 37 ISSN: 1536-0229 ISO Abbreviation: Clin Nucl Med Publication Date: 2012 Feb |
Date Detail:
|
Created Date: 2012-01-09 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7611109 Medline TA: Clin Nucl Med Country: United States |
Other Details:
|
Languages: eng Pagination: 121-7 Citation Subset: IM |
Affiliation:
|
From the *Institute of Pathology and Neuropathology, University Hospital of Essen, University of Duisburg-Essen, Essen, Germany; and †Clinic for Nuclear Medicine, University Hospital of Essen, University of Duisburg-Essen, Essen, Germany. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Investigating the Role of Grain Boundaries in CZTS and CZTSSe Thin Film Solar Cells with Scanning Pr...
Next Document: Combination of Preoperative Cerebral Blood Flow and 123I-Iomazenil SPECT Imaging Predicts Postoperat...