| Glucose transport across the blood-brain barrier in normal human subjects and patients with cerebral tumours studied using [11C]3-O-methyl-D-glucose and positron emission tomography. | |
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MedLine Citation:
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PMID: 3007547 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The kinetics of the regional cerebral uptake of [11C]3-O-methyl-D-glucose ([11C]MeG), a competitive inhibitor of D-glucose transport, have been studied in normal human subjects and patients with cerebral tumours using positron emission tomography (PET). Concomitant measurement of regional cerebral blood volume and blood flow enabled corrections for the contribution of intravascular tracer signal in PET scans to be carried out and regional unidirectional cerebral [11C]MeG extractions to be determined. A three-compartment model containing an arterial plasma and two cerebral compartments was required to produce satisfactory fits to experimental regional cerebral [11C]MeG uptake data. Under fasting, resting conditions, normal controls had mean unidirectional whole-brain, cortical, and white matter [11C]MeG extractions of 14, 13, and 17%, respectively. Mean values of k1 and k2, first-order rate constants describing forward and back transport, respectively, of tracer into the first cerebral compartment, were similar for [11C]MeG and [18F]2-fluoro-2-deoxy-D-glucose (18FDG), a second competitive inhibitor of D-glucose transport. k3, a rate constant describing FDG phosphorylation, was 20 times higher for cortical FDG uptake than the k3 fitted for [11C]MeG cortical uptake. Glioma [11C]MeG extractions ranged from normal levels of 12% to raised levels of 30%. Transport of [11C]MeG in and out of contralateral cortical tissue was significantly depressed in patients with gliomas. It is concluded that under fasting, resting conditions, regional cerebral glucose extraction remains relatively uniform throughout normal brain tissue. Gliomas, however, may have raised levels of glucose extraction. The nature of the second cerebral compartment required to describe [11C]MeG uptake is unclear, but it could represent either a useless phosphorylation-dephosphorylation cycle or nonspecific tracer uptake by a cerebral subcompartment. |
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Authors:
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D J Brooks; R P Beaney; A A Lammertsma; S Herold; D R Turton; S K Luthra; R S Frackowiak; D G Thomas; J Marshall; T Jones |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Volume: 6 ISSN: 0271-678X ISO Abbreviation: J. Cereb. Blood Flow Metab. Publication Date: 1986 Apr |
Date Detail:
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Created Date: 1986-05-12 Completed Date: 1986-05-12 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8112566 Medline TA: J Cereb Blood Flow Metab Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 230-9 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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3-O-Methylglucose Adult Aged Biological Transport Blood-Brain Barrier* Brain / metabolism, radionuclide imaging Brain Neoplasms / metabolism*, radionuclide imaging Female Glioblastoma / metabolism, radionuclide imaging Glioma / metabolism, radionuclide imaging Glucose / metabolism* Humans Kinetics Male Methylglucosides / diagnostic use* Methylglycosides / diagnostic use* Middle Aged Oligodendroglioma / metabolism, radionuclide imaging Tomography, Emission-Computed* |
| Chemical | |
Reg. No./Substance:
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0/Methylglucosides; 0/Methylglycosides; 146-72-5/3-O-Methylglucose; 50-99-7/Glucose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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