Document Detail

Glucose tolerance in the proximal versus the distal small bowel in Wistar rats.
MedLine Citation:
PMID:  18719969     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Type 2 diabetes is an epidemic and insulin resistance is the central etiology of this disease. Obesity increases insulin resistance and glucose intolerance and also exacerbates metabolic abnormalities present in type 2 diabetes. Bariatric surgery is the most effective treatment for severe obesity. Most reported series show that return to euglycemia and normal insulin levels occur days after gastric bypass and biliopancreatic diversion, long before major weight loss has taken place. The mechanisms underlying this dramatic reversal of type 2 diabetes following these bariatric procedures are not well understood. METHODS: Twelve Wistar rats were fed with a palatable hyperlipidic diet for 12 weeks. Body weight, glucose, and intraperitoneal glucose tolerance test were measured regularly. On day 91, they were randomized in two groups (hindgut and controls) and operated. Twenty-one days later, the tests were done again and the hindgut group re-operated. A duodenal exclusion was done. The results of an intraperitoneal glucose tolerance test were compared after the procedures. RESULTS: Body weight increased regularly in all the rats. Some rats developed hyperglycemia 28 days after beginning hyperlipidic diet, but these levels returned to baseline on days 56 and 84. The glucose tolerance test showed an improvement in glycemic levels in the hindgut group 21 days after the first operation (151 +/- 21mg/dl). After the second operation, despite weight loss, the glucose tolerance test of the foregut group worsened again (267 +/- 53 mg/dl) (p < 0.01). CONCLUSION: Comparing the "hindgut hypothesis" and the "foregut hypothesis", our data show an improvement in the 30 min glucose tolerance test in the hindgut group.
Marcus Vinicius Dantas de Campos Martins; Antônio Augusto Peixoto; Alberto Schanaider; Christiano Costa Esposito; Carolina Barreira Albano Aratanha
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Publication Detail:
Type:  Journal Article     Date:  2008-08-22
Journal Detail:
Title:  Obesity surgery     Volume:  19     ISSN:  0960-8923     ISO Abbreviation:  Obes Surg     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-01-21     Completed Date:  2009-04-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9106714     Medline TA:  Obes Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  202-6     Citation Subset:  IM    
Department of Surgery, Faculty of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
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MeSH Terms
Blood Glucose / metabolism
Diabetes Mellitus, Type 2 / complications,  diagnosis,  physiopathology,  surgery*
Disease Models, Animal
Glucose Intolerance / complications,  diagnosis,  metabolism*,  surgery*
Glucose Tolerance Test / methods
Intestine, Small / metabolism*,  surgery*
Obesity, Morbid / complications,  metabolism,  surgery
Random Allocation
Rats, Wistar
Treatment Outcome
Reg. No./Substance:
0/Blood Glucose

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