| Glucose-responsive micelles from self-assembly of poly(ethylene glycol)-b-poly(acrylic acid-co-acrylamidophenylboronic acid) and the controlled release of insulin. | |
| | |
MedLine Citation:
|
PMID: 19810675 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
|
Poly(ethylene glycol)-block-poly(acrylic acid-co-acrylamidophenylboronic acid) [PEG(114)-b-(PAA(63)-co-PAAPBA(107))] was synthesized by the modification of poly(ethylene glycol)-block-poly(acrylic acid) (PEG(114)-b-PAA(170)) with 3-aminophenylboronic acid (APBA). Glucose-responsive PEG(114)-b-(PAA(63)-co-PAAPBA(107)) self-assembled into core-shell micelles with the hydrophobic core composed of PAAPBA and hydrophilic shell composed of PEG in aqueous solution. The swelling and disaggregating behaviors of micelles responding to glucose were investigated by using light scattering in aqueous solution at pH 7.4. Characterization of insulin-loaded micelles and their drug release in solutions with various glucose concentrations were further studied. The results demonstrated that the drug release rate can be controlled by variation of glucose concentration. |
| | |
Authors:
|
Beilei Wang; Rujiang Ma; Gan Liu; Yan Li; Xiaojun Liu; Yingli An; Linqi Shi |
Related Documents
:
|
3898345 - Effect of ethanol and npg-gma on replica patterns on composite restorations performed i... 19120785 - Shear bond strength of a sealant to contaminated-enamel surface: influence of erbium : ... 20674365 - Nanostructured bacterial materials for innovative medicines. 3860145 - Synthetic polymers as drugs. 11843165 - The deprotonation of benzyl alcohol radical cations: a mechanistic dichotomy in the gas... 16534825 - Ionic solid-state dimers and polymers derived from imidazolium dicarboxylic acids. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Langmuir : the ACS journal of surfaces and colloids Volume: 25 ISSN: 1520-5827 ISO Abbreviation: Langmuir Publication Date: 2009 Nov |
Date Detail:
|
Created Date: 2009-10-27 Completed Date: 2009-12-28 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9882736 Medline TA: Langmuir Country: United States |
Other Details:
|
Languages: eng Pagination: 12522-8 Citation Subset: - |
Affiliation:
|
Key Laboratory of Functional Polymer Materials, Ministry of Education, and Institute of Polymer Chemistry, Nankai University, Tianjin 300071, China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Discovery of a Novel Class of Potent Coumarin Monoamine Oxidase B Inhibitors: Development and Biopha...
Next Document: Solid-state (49/47)Ti NMR of titanium-based MCM-41 hybrid materials.