Document Detail

Glucose regulation in preterm newborn infants.
MedLine Citation:
PMID:  17587854     Owner:  NLM     Status:  MEDLINE    
After birth, continuous transplacental transfer of glucose is interrupted. Neonates have to provide brain and vital organs with sufficient glucose. In term newborn infants, this is accomplished through well-coordinated hormonal and metabolic adaptive changes. During the first week of life, preterm infants are at high risk of abnormal glucose homeostasis. They are at risk of hypoglycemia due to limited glycogen and fat stores that should have occurred in the third trimester. Continuous glucose infusion is always required soon after birth to maintain the glucose level. However, under such conditions, many preterm infants develop hyperglycemia. Defective islet beta-cell processing of proinsulin is likely related to hyperglycemia. There is also evidence that preterm infants are partially resistant to insulin. By contrast with adults, hepatic glucose production is not suppressed during parenteral glucose infusion. Exogenous insulin infusion partially reduces endogenous glucose production in preterm newborn infants. This treatment is efficient and safe when used with caution. More research is needed to understand the specificity of glucose homeostasis in preterm infants and to evaluate the long-term consequences of metabolic and nutritional support during early life.
Delphine Mitanchez
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Publication Detail:
Type:  Journal Article; Review     Date:  2007-06-20
Journal Detail:
Title:  Hormone research     Volume:  68     ISSN:  1423-0046     ISO Abbreviation:  Horm. Res.     Publication Date:  2007  
Date Detail:
Created Date:  2007-11-06     Completed Date:  2007-12-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0366126     Medline TA:  Horm Res     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  265-71     Citation Subset:  IM    
Copyright Information:
(c) 2007 S. Karger AG, Basel.
Université Pierre et Marie Curie, Faculté de Médecine, Service de néonatologie, AP-HP, Hôpital Armand-Trousseau, Paris, France.
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MeSH Terms
Blood Glucose / metabolism*
Homeostasis / physiology*
Hyperglycemia / metabolism*,  physiopathology
Hypoglycemia / metabolism*,  physiopathology
Infant, Newborn
Infant, Premature / metabolism*
Reg. No./Substance:
0/Blood Glucose

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