| Glucose and pyruvate metabolism in severe chronic obstructive pulmonary disease. | |
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MedLine Citation:
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PMID: 22016370 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The mechanisms leading to weight loss in patients with chronic obstructive pulmonary disease (COPD) are poorly understood, but may involve alterations in macronutrient metabolism. Changes in muscle oxidative capacity and lactate production during exercise suggest glucose metabolism may be altered in COPD subjects. The objective of this study was to determine differences in the rates of glucose production and clearance, the rate of glycolysis (pyruvate production), and oxidative and non-oxidative pyruvate disposal in subjects with severe COPD compared to healthy controls. The in vivo rates of glucose production and clearance were measured in fourteen stable outpatients with severe COPD (seven with low and seven with preserved body mass indices) and seven healthy controls using an intravenous infusion of (2)H(2)-glucose. Additionally, pyruvate production and oxidative and non-oxidative pyruvate disposal were measured using intravenous infusions of (13)C-bicarbonate and (13)C-pyruvate. Endogenous glucose flux and glucose clearance were significantly faster in the combined COPD subjects (p=0.002 and p<0.001 respectively). This difference remained significant when COPD subjects were separated by body mass index. Pyruvate flux and oxidation were significantly higher in the combined COPD subjects than controls (p=0.02 for both), but there was no difference in non-oxidative pyruvate disposal or plasma lactate concentrations between the two groups. In subjects with severe COPD, there are alterations in glucose metabolism, leading to increased glucose production and faster glucose metabolism by glycolysis and oxidation compared to controls. However, no difference in glucose conversion to lactate via pyruvate reduction is observed. |
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Authors:
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Christina C Kao; Jean W-C Hsu; Venkata Bandi; Nicola A Hanania; Farrah Kheradmand; Farook Jahoor |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-10-20 |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: - ISSN: 1522-1601 ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-10-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1Baylor College of Medicine. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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