| Glucose metabolism parameters during an oral glucose tolerance test in patients with autosomal dominant polycystic kidney disease. | |
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MedLine Citation:
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PMID: 20961181 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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OBJECTIVE: The aim of the study was to estimate the pancreatic beta cell function and insulin resistance indexes in a group of Autosomal Dominant Polycystic Kidney Disease (ADPKD) patients with normal kidney function and no previous diabetes mellitus diagnosis. METHODS: A total of 49 adult patients with ADPKD aged 36 ± 11 years, and 50 healthy controls, all of Caucasian origin, were included in the study. Blood glucose, insulin and C-peptide concentrations were measured during an oral glucose tolerance test (OGTT with 75 g glucose) performed according to WHO recommendations in all subjects. RESULTS: The insulin/glucose ratio at the 30th and 120th minute of the OGTT and the insulinogenic index [(insulin at 30 min - insulin at 0 min)/glucose at 30 min] were significantly lower (p = 0.018, p = 0.031 and p = 0.013, respectively) in the ADPKD group. Four other indexes of beta cell function were lower with the borderline statistical significance (p = 0.054-0.076) than in controls. None of the calculated insulin sensitivity indexes differed between the study and control groups. CONCLUSIONS: Presence of ADPKD in patients with normal kidney function is associated with impaired beta cell function after an oral glucose load, without a significant decrease in insulin sensitivity. |
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Authors:
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Maria Pietrzak-Nowacka; Krzysztof Safranow; Elżbieta Byra; Monika Nowosiad; Małgorzata Marchelek-Myśliwiec; Kazimierz Ciechanowski |
Publication Detail:
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Type: Journal Article Date: 2010-10-20 |
Journal Detail:
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Title: Scandinavian journal of clinical and laboratory investigation Volume: 70 ISSN: 1502-7686 ISO Abbreviation: Scand. J. Clin. Lab. Invest. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0404375 Medline TA: Scand J Clin Lab Invest Country: England |
Other Details:
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Languages: eng Pagination: 561-7 Citation Subset: IM |
Affiliation:
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Department of Nephrology, Transplantology and Internal Medicine, Pomeranian Medical University, Szczecin, Poland. mariola.nowacka@o2.pl |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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