Document Detail

Glucose metabolism in the rat frontal cortex recovered without the recovery of choline acetyltransferase activity after lesioning of the nucleus basalis magnocellularis.
MedLine Citation:
PMID:  10696799     Owner:  NLM     Status:  MEDLINE    
We measured the cerebral metabolic rate of glucose (CMRglc) by using positron emission tomography (PET) with [18F]fluorodeoxyglucose (FDG) and the choline acetyltransferase (ChAT) activity at 3 days and 3 months after destruction of the nucleus basalis magnocellularis (NBM). Although the frontal ChAT activity remained 20% lower than that of controls even at 3 months post-lesioning, the frontal CMRglc, which was reduced by 40% at 3 days, returned to normal at 3 months, namely CMRglc recovered with time without the recovery of ChAT activity with time. Since glucose metabolism reflects mainly presynaptic neuronal activity, we speculate that presynaptic rearrangement may have some relation to the recovery of CMRglc.
Y Katsumi; T Hayashi; C Oyanagi; Y Nagahama; H Yamauchi; S Ono; H Fukuyama; H Shibasaki
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuroscience letters     Volume:  280     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  2000 Feb 
Date Detail:
Created Date:  2000-03-13     Completed Date:  2000-03-13     Revised Date:  2010-02-25    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  9-12     Citation Subset:  IM    
Department of Neurology, Graduate School of Medicine, Kyoto University, Japan.
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MeSH Terms
Basal Nucleus of Meynert / drug effects,  physiology*
Choline O-Acetyltransferase / metabolism*
Frontal Lobe / drug effects,  metabolism*
Glucose / metabolism*
Ibotenic Acid / toxicity
Neurotoxins / toxicity
Rats, Wistar
Reference Values
Time Factors
Reg. No./Substance:
0/Neurotoxins; 2552-55-8/Ibotenic Acid; 50-99-7/Glucose; EC O-Acetyltransferase

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