| Glucose metabolism and gray-matter concentration in apolipoprotein E ε4 positive normal subjects. | |
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MedLine Citation:
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PMID: 22188720 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Apolipoprotein E (ApoE) ε4 is known as a genetic risk factor for Alzheimer's disease (AD). This study investigated the prevalence of imaging abnormalities suggestive of AD in cognitively normal ApoE ε4 carriers using (18)F-fluorodeoxyglucose (FDG) positron emission tomography (PET) and voxel-based morphometry (VBM). Forty-five cognitive normal ApoE ε4 allele carriers and 45 noncarriers underwent both FDG positron emission tomography and magnetic resonance imaging (MRI). A total of 90 normal database sets were generated for the individual 45 ε4 carriers and 45 noncarriers. Mean z-scores in the predefined AD-specific regions of interest (ROI) were calculated for each ε4 carrier and noncarrier using the individually defined normal database. The prevalence of AD-like hypometabolism and atrophy in the ε4 carriers was 8.9% and 17.7%, respectively, and did not differ significantly from those in the noncarriers (8.9%, 8.8%). The majority of ε4 carriers showed preserved FDG uptake or gray matter concentration. |
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Authors:
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Miharu Samuraki; Ichiro Matsunari; Wei-Ping Chen; Keisuke Shima; Daisuke Yanase; Nozomi Takeda; Hiroshi Matsuda; Masahito Yamada |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-19 |
Journal Detail:
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Title: Neurobiology of aging Volume: - ISSN: 1558-1497 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8100437 Medline TA: Neurobiol Aging Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Science, Kanazawa-city, Ishikawa, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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