| Glucose lowering efficacy of the aqueous stem bark extract of Trema orientalis (Linn) Blume in normal and streptozotocin diabetic rats. | |
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MedLine Citation:
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PMID: 16599266 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The glucose-lowering efficacy of the aqueous stem bark extract of Trema orientalis (Ulmaceae) was evaluated both in normal and streptozotocin-induced diabetic rats. In normoglycemic rats, the single oral administration of the aqueous extract of T. orientalis failed to reduce blood glucose levels while in STZ-diabetic rats, the plant extract (38-300 mg/kg) exhibited significant hypoglycaemic activity with a maximum effect of 29.67%, 5 hours after administration of the 75 mg/kg dose when compared with the diabetic untreated group. Glibenclamide was not able to lower blood glucose in STZ-diabetic rats, while it significantly lowered the blood sugar in normoglycemic rats. The hypoglycaemic property of T. orientalis was also assessed by an oral glucose tolerance test (OGTT) in STZ-diabetic rats. The aqueous extract of T. orientalis and the reference drug, glibenclamide, (10 mg/kg) produced significant blood glucose lowering effects in the diabetic rats when compared to the diabetic controls. One week after repeated administration of T. orientalis extract, blood glucose levels were significantly decreased (p < 0.05) and still remained low after 2 weeks (p < 0.01). The results indicated that T. orientalis stem bark extract significantly reduces blood glucose in STZ-induced diabetic rats by a mechanism different from that of sulfonylurea agents. The present investigation provides pharmacological evidence that the use of this plant extract in traditional medicine for cardiovascular disease can be of benefit particulary in diabetic patients. |
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Authors:
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T Dimo; F T Ngueguim; P Kamtchouing; E Dongo; P V Tan |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Die Pharmazie Volume: 61 ISSN: 0031-7144 ISO Abbreviation: Pharmazie Publication Date: 2006 Mar |
Date Detail:
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Created Date: 2006-04-07 Completed Date: 2006-05-17 Revised Date: 2007-01-29 |
Medline Journal Info:
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Nlm Unique ID: 9800766 Medline TA: Pharmazie Country: Germany |
Other Details:
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Languages: eng Pagination: 233-6 Citation Subset: IM |
Affiliation:
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Department of Animal Biology and Physiology, Faculty of Science, P.O. Box 812 University of Yaounde I, Cameroon. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Glucose / metabolism Body Weight / drug effects Diabetes Mellitus, Experimental / blood, drug therapy* Diabetes Mellitus, Type 1 / blood, chemically induced, drug therapy Drinking / drug effects Eating / drug effects Glucose Tolerance Test Hypoglycemic Agents / pharmacology*, therapeutic use Male Plant Bark / chemistry Plant Extracts / pharmacology Rats Rats, Wistar Trema / chemistry* |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Hypoglycemic Agents; 0/Plant Extracts |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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