| Glucose kinetics and pregnancy outcome in Indian women with low and normal body mass indices. | |
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MedLine Citation:
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PMID: 19471289 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND/OBJECTIVES: Fetal energy demands are met from the oxidation of maternally supplied glucose and amino acids. During the fasted state, the glucose supply is thought to be met by gluconeogenesis. Underweight women with low body mass index (BMI) might be unable to adequately supply amino acids to satisfy the demands of gluconeogenesis. SUBJECTS/METHODS: Glucose kinetics were measured during the first and second trimesters of pregnancy in 10 low-BMI and 10 normal-BMI pregnant women at the 12th hour of an overnight fast using a primed 6 h U-(13)C glucose infusion and was correlated to maternal dietary and anthropometric variables and birth weight. RESULTS: Low-BMI mothers consumed more energy, carbohydrates and protein, had faster glucose production (R (a)) and oxidation rates in the first trimester. In the same trimester, dietary energy and carbohydrate correlated with glucose production, glycogenolysis and glucose oxidation in all women. Both groups had similar rates of gluconeogenesis in the first and second trimesters. Glucose R (a) in the second trimester was weakly correlated with the birth weight (r=0.4, P=0.07). CONCLUSIONS: Maternal energy and carbohydrate intakes, not BMI, appear to influence glucose R (a) and oxidation in early and mid pregnancy. |
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Authors:
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P Dwarkanath; A V Kurpad; S Muthayya; T Thomas; A Mhaskar; R Mhaskar; A Thomas; M Vaz; F Jahoor |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. Date: 2009-05-27 |
Journal Detail:
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Title: European journal of clinical nutrition Volume: 63 ISSN: 1476-5640 ISO Abbreviation: Eur J Clin Nutr Publication Date: 2009 Nov |
Date Detail:
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Created Date: 2009-11-05 Completed Date: 2010-01-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8804070 Medline TA: Eur J Clin Nutr Country: England |
Other Details:
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Languages: eng Pagination: 1327-34 Citation Subset: IM |
Affiliation:
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St John's Research Institute, St John's National Academy of Health Sciences, Bangalore, Karnataka, India. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Body Mass Index* Breath Tests Carbon Isotopes Dietary Carbohydrates / administration & dosage* Energy Intake / physiology* Female Gluconeogenesis / physiology* Glucose / metabolism, pharmacokinetics* Humans India Infant, Low Birth Weight Infant, Newborn Oxidation-Reduction Pregnancy Pregnancy Outcome* Pregnancy Trimester, First / metabolism Pregnancy Trimester, Second / metabolism Weight Gain / physiology Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Carbon Isotopes; 0/Dietary Carbohydrates; 50-99-7/Glucose |
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