Document Detail

Glucose kinetics following administration of an intravenous fat emulsion to low-birth-weight neonates.
MedLine Citation:
PMID:  1443115     Owner:  NLM     Status:  MEDLINE    
To evaluate the mechanism(s) of the observed increase in plasma glucose concentration following the administration of an intravenous fat emulsion to the neonate, we measured glucose kinetics in eight low-birth-weight neonates by the prime constant rate infusion technique with D-[6,6-2H2]glucose at a rate of 0.22 +/- 0.01 x min-1 (39.4 +/- 1.3 x min-1) while the neonates received 32 +/- 5 x min-1 glucose (6.3 +/- 1.1 x min-1) plus an amino acid mixture (parenteral alimentation) alone and in combination with an intravenous fat emulsion (Intralipid). Following the latter combination, there were significant increases in plasma glucose concentration [4.07 +/- 0.11 (73 +/- 2 mg/dl) to 5.00 +/- 0.22 mmol/l (90 +/- 4 mg/dl); P < 0.01] and in plasma insulin concentration [72 +/- 14 (10 +/- 2 microU/ml) to 172 +/- 36 pmol/l (24 +/- 5 microU/ml); P < 0.05]. The parenteral alimentation and intravenous fat effusion combination did not affect the glucose production rate: 0.15 +/- 0.05 x min-1 (0.03 +/- 0.01 x min-1) during the parenteral alimentation alone and 0.16 +/- 0.05 x min-1 (0.03 +/- 0.01 x min-1) when parenteral alimentation was combined with an intravenous fat emulsion. We conclude that the increased plasma glucose concentration seen in association with administration of parenteral alimentation combined with an intravenous fat emulsion to the premature neonate is not due to enhanced glucose production but could be the result of alterations in glucose utilization.
K A Yunis; W Oh; S Kalhan; R M Cowett
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  263     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1992 Nov 
Date Detail:
Created Date:  1992-12-23     Completed Date:  1992-12-23     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  E844-9     Citation Subset:  IM    
Department of Pediatrics, Women and Infants Hospital of Rhode Island, Providence.
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MeSH Terms
Blood Glucose / analysis
Fat Emulsions, Intravenous / pharmacology*
Fatty Acids, Nonesterified / blood
Glucose / pharmacokinetics*
Infant, Low Birth Weight / metabolism*
Infant, Newborn
Parenteral Nutrition
Grant Support
Reg. No./Substance:
0/Blood Glucose; 0/Fat Emulsions, Intravenous; 0/Fatty Acids, Nonesterified; 50-99-7/Glucose

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