| Glucose kinetics differ between women and men, during and after exercise. | |
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MedLine Citation:
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PMID: 16714415 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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As exercise can improve the regulation of glucose and carbohydrate metabolism, it is important to establish biological factors, such as sex, that may influence these outcomes. Glucose kinetics, therefore, were compared between women and men at rest, during exercise, and postexercise. It was hypothesized that glucose flux would be significantly lower in women than men during both the exercise and postexercise periods. Subjects included normal weight, healthy, eumenorrehic women and men, matched for habitual activity level and maximal oxygen uptake per kilogram lean body mass. Testing occurred following 3 days of diet control, with no exercise the day before. Subjects were tested in the overnight-fasted condition with women studied in the midluteal phase of the menstrual cycle. Resting (120 min), exercise (85% lactate threshold, 90 min), and postexercise (180 min) measurements of glucose flux and substrate metabolism were made. During exercise, women had a significantly lower rate of glucose appearance (Ra) (P<0.001) and disappearance (Rd) (P<0.002) compared with men. Maximal values were achieved at 90 min of exercise for both glucose Ra (mean+/-SE: 22.8+/-1.12 micromol.kg body wt-1.min-1 women and 33.6+/-1.79 micromol.kg body wt-1.min-1 men) and glucose Rd (23.2+/-1.26 and 34.1+/-1.71 micromol.kg body wt-1.min-1, respectively). Exercise epinephrine concentration was significantly lower in women compared with men (P<0.02), as was the increment in glucagon from rest to exercise (P<0.04). During the postexercise period, glucose Ra and Rd were also significantly lower in women vs. men (P<0.001), with differences diminishing over time. In conclusion, circulating blood glucose flux was significantly lower during 90 min of moderate exercise, and immediately postexercise, in women compared with men. Sex differences in the glucagon increase to exercise, and/or the epinephrine levels during exercise, may play a role in determining these sex differences in exercise glucose turnover. |
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Authors:
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Tracy J Horton; Gary K Grunwald; Jennifer Lavely; W Troy Donahoo |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: 100 ISSN: 8750-7587 ISO Abbreviation: J. Appl. Physiol. Publication Date: 2006 Jun |
Date Detail:
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Created Date: 2006-05-22 Completed Date: 2006-08-04 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: United States |
Other Details:
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Languages: eng Pagination: 1883-94 Citation Subset: IM |
Affiliation:
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Section of Nutrition, Box C225, Department of Pediatrics, University of Colorado Health Sciences Center, 4200 East 9th Ave., and Department of Preventive Medicine, Kaiser Permanente, Denver, CO 80262, USA. tracy.horton@uchsc.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Glucose / analysis Body Mass Index Carbohydrate Metabolism / physiology Energy Metabolism / physiology Epinephrine / blood Exercise / physiology* Female Glucose / metabolism* Glycogen / metabolism Humans Male Middle Aged Sex Characteristics* Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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DK-48520/DK/NIDDK NIH HHS; HL-04226/HL/NHLBI NIH HHS; HL-59331/HL/NHLBI NIH HHS; M01 RR-00051/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 50-99-7/Glucose; 51-43-4/Epinephrine; 9005-79-2/Glycogen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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