Document Detail

Glucose kinetics differ between women and men, during and after exercise.
MedLine Citation:
PMID:  16714415     Owner:  NLM     Status:  MEDLINE    
As exercise can improve the regulation of glucose and carbohydrate metabolism, it is important to establish biological factors, such as sex, that may influence these outcomes. Glucose kinetics, therefore, were compared between women and men at rest, during exercise, and postexercise. It was hypothesized that glucose flux would be significantly lower in women than men during both the exercise and postexercise periods. Subjects included normal weight, healthy, eumenorrehic women and men, matched for habitual activity level and maximal oxygen uptake per kilogram lean body mass. Testing occurred following 3 days of diet control, with no exercise the day before. Subjects were tested in the overnight-fasted condition with women studied in the midluteal phase of the menstrual cycle. Resting (120 min), exercise (85% lactate threshold, 90 min), and postexercise (180 min) measurements of glucose flux and substrate metabolism were made. During exercise, women had a significantly lower rate of glucose appearance (Ra) (P<0.001) and disappearance (Rd) (P<0.002) compared with men. Maximal values were achieved at 90 min of exercise for both glucose Ra (mean+/-SE: 22.8+/-1.12 body wt-1.min-1 women and 33.6+/-1.79 body wt-1.min-1 men) and glucose Rd (23.2+/-1.26 and 34.1+/-1.71 body wt-1.min-1, respectively). Exercise epinephrine concentration was significantly lower in women compared with men (P<0.02), as was the increment in glucagon from rest to exercise (P<0.04). During the postexercise period, glucose Ra and Rd were also significantly lower in women vs. men (P<0.001), with differences diminishing over time. In conclusion, circulating blood glucose flux was significantly lower during 90 min of moderate exercise, and immediately postexercise, in women compared with men. Sex differences in the glucagon increase to exercise, and/or the epinephrine levels during exercise, may play a role in determining these sex differences in exercise glucose turnover.
Tracy J Horton; Gary K Grunwald; Jennifer Lavely; W Troy Donahoo
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  100     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-05-22     Completed Date:  2006-08-04     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1883-94     Citation Subset:  IM    
Section of Nutrition, Box C225, Department of Pediatrics, University of Colorado Health Sciences Center, 4200 East 9th Ave., and Department of Preventive Medicine, Kaiser Permanente, Denver, CO 80262, USA.
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MeSH Terms
Blood Glucose / analysis
Body Mass Index
Carbohydrate Metabolism / physiology
Energy Metabolism / physiology
Epinephrine / blood
Exercise / physiology*
Glucose / metabolism*
Glycogen / metabolism
Middle Aged
Sex Characteristics*
Time Factors
Grant Support
Reg. No./Substance:
0/Blood Glucose; 50-99-7/Glucose; 51-43-4/Epinephrine; 9005-79-2/Glycogen

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