Document Detail

Glucose intolerance induced by a high-fat/low-carbohydrate diet in rats effects of nonesterified fatty acids.
MedLine Citation:
PMID:  12108518     Owner:  NLM     Status:  MEDLINE    
We examined the time course of effects of a high-fat/low-carbohydrate (HF/LC) diet on the impairment of glucose tolerance in rats, clarified whether insulin secretion and sensitivity were impaired by the HF/LC diet, and investigated the relationship between the increased nonesterified fatty acids (NEFA) after HF/LC diet feeding and insulin secretion and sensitivity. We found that glucose tolerance and the postglucose-loading insulin secretion were impaired after 3 and 7 d on the HF/LC diet. The glucose intolerance was accompanied by a rise in the fasting plasma NEFA level. When stimulated with 15 mmol/L of glucose, the insulin secretion was impaired in pancreatic islets from rats fed the HF/LC diet. Rats fed the HF/LC diet showed insulin resistance in vivo. The glucose-stimulated insulin secretion was inhibited in the islets following 24-h culture with palmitic acid. The 24-h infusion of palmitic acid decreased whole-body insulin sensitivity. In summary, at least 3 d on a HF/LC diet is needed to induce glucose intolerance in rats, and the impairment may be induced by decreased insulin secretion and sensitivity, which is related to the increase in the plasma NEFA level.
Yuan Wang; Yoshikazu Miura; Takashi Kaneko; Jue Li; Li-Qiang Qin; Pei-Yu Wang; Hisao Matsui; Akio Sato
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Endocrine     Volume:  17     ISSN:  1355-008X     ISO Abbreviation:  Endocrine     Publication Date:  2002 Apr 
Date Detail:
Created Date:  2002-07-10     Completed Date:  2002-12-24     Revised Date:  2010-06-24    
Medline Journal Info:
Nlm Unique ID:  9434444     Medline TA:  Endocrine     Country:  United States    
Other Details:
Languages:  eng     Pagination:  185-91     Citation Subset:  IM    
Department of Environmental Health, Medical University of Yamanashi, Tamaho, Japan.
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MeSH Terms
Area Under Curve
Blood Glucose / metabolism
Dietary Carbohydrates / pharmacology*
Dietary Fats / pharmacology*
Fatty Acids, Nonesterified / blood
Glucose / pharmacology
Glucose Intolerance / chemically induced*
Glucose Tolerance Test
Insulin / blood
Islets of Langerhans / drug effects,  metabolism
Palmitic Acid / pharmacology
Rats, Wistar
Reg. No./Substance:
0/Blood Glucose; 0/Dietary Carbohydrates; 0/Dietary Fats; 0/Fatty Acids, Nonesterified; 11061-68-0/Insulin; 50-99-7/Glucose; 57-10-3/Palmitic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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