Document Detail

Glucose infusions into peripheral veins in the management of neonatal hypoglycemia--20% instead of 15%?
MedLine Citation:
PMID:  19397539     Owner:  NLM     Status:  MEDLINE    
AIM: To establish whether peripheral intravenous 20% glucose solutions would cause less local irritation, fewer cannulation changes and less weight gain than 15% glucose in newborn infants. METHODS: A total of 121 newborn infants with hypoglycemia were randomized to receive either 20% (group 20%, 60 infants) or 15% (group 15%, 61 infants) glucose infusions, which were initiated at 8 mg/kg/min rates and tapered according to the blood glucose levels. When the cannulation site had to be changed, signs of phlebitis at the previous cannulation site were scored (0-3). Number of cannulation site changes, durations of infusions and the infants' daily weights were recorded. RESULTS: The median durations of infusions in groups 20 and 15% were 4 (range 2-7) days versus 4 (range 2-8) days and the median number of cannulation site changes were 1 (range 0-6) versus 1 (range 0-5), respectively. Thirty-six infants in group 20% and 37 in group 15% developed some phlebitis, median severity scores being 1 (range 0-7) versus 15% 1 (range 0-8). The weights during the treatment were also similar. CONCLUSION: 20% and 15% glucose solutions can be infused equally safely into peripheral veins in neonates.
T Vanhatalo; O Tammela
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2009-04-14
Journal Detail:
Title:  Acta paediatrica (Oslo, Norway : 1992)     Volume:  99     ISSN:  1651-2227     ISO Abbreviation:  Acta Paediatr.     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-03-31     Completed Date:  2010-06-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9205968     Medline TA:  Acta Paediatr     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  350-3     Citation Subset:  IM    
Department of Pediatrics, Pediatric Research Centre, Tampere University Hospital, Tampere, Finland.
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MeSH Terms
Catheterization, Peripheral
Glucose / administration & dosage*,  adverse effects
Hypoglycemia / drug therapy*
Infant, Newborn
Infusions, Intravenous
Phlebitis / chemically induced
Severity of Illness Index
Treatment Outcome
Weight Gain
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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