| Glucose homeostasis in rainbow trout fed a high-carbohydrate diet: metformin and insulin interact in a tissue-dependent manner. | |
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MedLine Citation:
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PMID: 21068202 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Carnivorous fish species such as the rainbow trout (Oncorhynchus mykiss) are considered to be "glucose intolerant" because of the prolonged hyperglycemia experienced after intake of a carbohydrate-enriched meal. In the present study, we use this species to study glucose homeostasis in fish chronically infused with the hypoglycemic agents, insulin, and metformin, and fed with a high proportion of carbohydrates (30%). We analyzed liver, skeletal muscle, and white adipose tissue (WAT), which are insulin- and metformin-specific targets at both the biochemical and molecular levels. Trout infused with the combination of insulin and metformin can effectively utilize dietary glucose at the liver, resulting in lowered glycemia, increased insulin sensitivity, and glucose storage capacity, combined with reduced glucose output. However, in both WAT and skeletal muscle, we observed decreased insulin sensitivity with the combined insulin + metformin treatment, resulting in the absence of changes at the metabolic level in the skeletal muscle and an increased potential for glucose uptake and storage in the WAT. Thus, the poor utilization by rainbow trout of a diet with a high proportion of carbohydrate can at least be partially improved by a combined treatment with insulin and metformin, and the glucose intolerance observed in this species could be, in part, due to some of the downstream components of the insulin and metformin signaling pathways. However, the predominant effects of metformin treatment on the action of insulin in these three tissues thought to be involved in glucose homeostasis remain exclusive in this species. |
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Authors:
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S Polakof; T W Moon; P Aguirre; S Skiba-Cassy; S Panserat |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2010-11-10 |
Journal Detail:
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Title: American journal of physiology. Regulatory, integrative and comparative physiology Volume: 300 ISSN: 1522-1490 ISO Abbreviation: Am. J. Physiol. Regul. Integr. Comp. Physiol. Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2010-12-24 Completed Date: 2011-01-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100901230 Medline TA: Am J Physiol Regul Integr Comp Physiol Country: United States |
Other Details:
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Languages: eng Pagination: R166-74 Citation Subset: IM |
Affiliation:
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Institut National de la Recherche Agronomique, UMR Nutrition Aquaculture et Génomique, Saint-Pée-sur-Nivelle, France. spolakof@st-pee.inra.fr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adipose Tissue, White
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metabolism Administration, Oral Animals Blood Glucose / metabolism Dietary Carbohydrates / administration & dosage, pharmacology* Drug Interactions Glucose / metabolism* Homeostasis / drug effects*, physiology Hypoglycemic Agents / pharmacology Infusion Pumps Insulin / administration & dosage, pharmacology* Liver / metabolism Metformin / administration & dosage, pharmacology* Models, Animal Muscle, Skeletal / metabolism Oncorhynchus mykiss / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Dietary Carbohydrates; 0/Hypoglycemic Agents; 11061-68-0/Insulin; 50-99-7/Glucose; 657-24-9/Metformin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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