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Glucose homeostasis in adults with Prader-Willi syndrome during treatment with growth hormone: Results from a 12-month prospective study.
MedLine Citation:
PMID:  24360789     Owner:  NLM     Status:  Publisher    
OBJECTIVES: To investigate glucose homeostasis in relation to body mass index (BMI) in adults with PWS before and after GH therapy.
DESIGN: We prospectively investigated the effects of a 12-month GH treatment on body composition and glucose homeostasis in relation to BMI in 39 adults, mean (±SD) age=28.6 (6.5) years with genetically verified PWS. We compared the results for different BMI categories (<25kg/m(2); 25-30kg/m(2); >30kg/m(2)) and performed a regression analysis to detect predictors for homeostasis model of assessment-insulin resistance (HOMA-IR).
RESULTS: The baseline HOMA-IR was higher, with BMI of >30kg/m(2). Our main findings were as follows: i) GH treatment (mean final dose, 0.6 (0.25) mg) was associated with small increases in fasting p-glucose, 2-h p-glucose by oral glucose load tolerance test, HOMA-IR and lean mass, and a reduction in fat mass. ii) Whereas the baseline HOMA-IR was associated with increased BMI (>30kg/m(2)), we found no differences in HOMA-IR among the BMI categories after 12months of GH. iii) Stepwise linear regression identified the triglyceride level as the strongest predictor of HOMA-IR at baseline, whereas an increase in VAT was the strongest predictor of the increase in HOMA-IR after therapy.
CONCLUSIONS: GH treatment for 12months in adults with PWS resulted in an increase in HOMA-IR, irrespective of BMI, confirming that control of HbA1c is essential during GH treatment in PWS.
Anders Palmstrøm Jørgensen; Thor Ueland; Rasmus Sode-Carlsen; Thomas Schreiner; Kai Fredrik Rabben; Stense Farholt; Charlotte Høybye; Jens Sandahl Christiansen; Jens Bollerslev
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-12-4
Journal Detail:
Title:  Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society     Volume:  -     ISSN:  1532-2238     ISO Abbreviation:  Growth Horm. IGF Res.     Publication Date:  2013 Dec 
Date Detail:
Created Date:  2013-12-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9814320     Medline TA:  Growth Horm IGF Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013 Elsevier Ltd. All rights reserved.
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