| Glucose dysregulation and hepatic steatosis in obese adolescents: is there a link? | |
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MedLine Citation:
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PMID: 19434725 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Fatty liver is increasingly common in obese adolescents. We determined its association with glucose dysregulation in 118 (37M/81F) obese adolescents of similar age and percent total fat. Fast-magnetic resonance imaging (MRI) and simple MRI were used to quantify hepatic fat content and abdominal fat distribution. All subjects had a standard oral glucose tolerance test. Insulin sensitivity was estimated by the Matsuda Index and homeostasis model assessment of insulin resistance. Baseline total and high molecular weight (HMW)-adiponectin and interleukin (IL)-6 levels were measured. The cohort was stratified according to tertiles of hepatic fat content. Whereas age and %fat were comparable across tertiles, ethnicity differed in that fewer Blacks and more Whites and Hispanics were in the moderate and high category of hepatic fat fraction (HFF). Visceral and the visceral-to-subcutaneous fat ratio increased and insulin sensitivity decreased across tertiles. Two-hour plasma glucose rose with increasing hepatic steatosis (P < 0.008). 73.7% of the subjects in the high HFF had the metabolic syndrome compared to 19.5% and 30.6%, respectively, in the low and moderate categories. Both total and HMW-adiponectin decreased, and IL-6 increased with increasing hepatic steatosis. CONCLUSION: In obese adolescents, independent of total fat, increasing severity of fatty liver is associated with glucose dysregulation, metabolic syndrome, and with a proinflammatory milieu. |
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Authors:
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Anna M G Cali; Ana Mayra De Oliveira; Hyeonjin Kim; Shu Chen; Miguel Reyes-Mugica; Sandra Escalera; James Dziura; Sara E Taksali; Romy Kursawe; Melissa Shaw; Mary Savoye; Bridget Pierpont; R Todd Constable; Sonia Caprio |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Hepatology (Baltimore, Md.) Volume: 49 ISSN: 1527-3350 ISO Abbreviation: Hepatology Publication Date: 2009 Jun |
Date Detail:
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Created Date: 2009-06-03 Completed Date: 2009-07-01 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 8302946 Medline TA: Hepatology Country: United States |
Other Details:
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Languages: eng Pagination: 1896-903 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Fatty Liver / complications*, metabolism* Female Glucose / metabolism* Humans Male Obesity / complications*, metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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K24-HD01464/HD/NICHD NIH HHS; R01 HD040787-09/HD/NICHD NIH HHS; R01-EB006494/EB/NIBIB NIH HHS; R01-HD20816/HD/NICHD NIH HHS; R01-HD40787/HD/NICHD NIH HHS; UL1 RR0249139/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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50-99-7/Glucose |
| Comments/Corrections | |
Comment In:
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Hepatology. 2009 Jul;50(1):328-9; author reply 329
[PMID:
19496178
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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