| Glucose depletion enhances sensitivity to shear stress-induced mechanical damage in red blood cells by rotary blood pumps. | |
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MedLine Citation:
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PMID: 19775265 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The metabolic process in red blood cells (RBCs) is anaerobic. The life-dependent adenosine triphosphate (ATP) for survival of cells is produced through glycolytic process. The aim of the study was to evaluate the effects of the glucose level on the mean corpuscular volume, mean corpuscular hemoglobin concentration, and hemolysis rate during hemolysis study by rotary blood pumps. The shear stress generated by rotary blood pumps may enhance glucose utilization by RBCs with depletion of glucose affecting ATP production and, consequently, cell size, shape, and morphology. The shear stress increases metabolism of RBCs consuming more energy ATP which is produced anaerobically from glycolytic process. Hence, in the closed circuit testing of rotary blood pumps, depletion of glucose might occur after prolonged pumping, which in turn affects metabolic process of RBCs by changing their size, shape, and morphology. It is thus suggested to monitor and control the glucose level of the fluid that suspends RBCs depending on the study duration. |
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Authors:
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Daisuke Sakota; Ryuki Sakamoto; Naoyuki Yokoyama; Mariko Kobayashi; Setsuo Takatani |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Artificial organs Volume: 33 ISSN: 1525-1594 ISO Abbreviation: Artif Organs Publication Date: 2009 Sep |
Date Detail:
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Created Date: 2009-09-24 Completed Date: 2009-12-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7802778 Medline TA: Artif Organs Country: United States |
Other Details:
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Languages: eng Pagination: 733-9 Citation Subset: IM |
Affiliation:
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Department of Artificial Organs, Tokyo Medical and Dental University, Tokyo, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine Triphosphate
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blood Animals Blood Glucose / metabolism* Equipment Design Erythrocyte Deformability* Erythrocyte Indices Erythrocytes / metabolism*, pathology Glycolysis* Heart-Assist Devices / adverse effects* Hemoglobins / metabolism Hemolysis* Isotonic Solutions Osmotic Pressure Rotation Stress, Mechanical Swine Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Hemoglobins; 0/Isotonic Solutions; 56-65-5/Adenosine Triphosphate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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