Document Detail

Glucose-dependent insulinotropic polypeptide augmentation of insulin. Physiology or pharmacology?
MedLine Citation:
PMID:  6368294     Owner:  NLM     Status:  MEDLINE    
Glucose-dependent insulinotropic polypeptide (GIP) is said to be a major physiologic factor in the augmentation of the insulin response to oral glucose. Whether GIP promotes insulin release at physiologic concentrations of glucose or GIP, however, is questionable. To investigate this further, volunteers were infused with 10, 20, or 40 g intravenous (i.v.) glucose, with or without simultaneous GIP infusion, to produce plasma levels of GIP or glucose similar to those seen after oral glucose. The effect of 40 g i.v. glucose with three times the original dose of GIP was also investigated. No significant enhancement of glucose-stimulated insulin secretion was seen when GIP was infused with 10 or 20 g i.v. glucose; however, with 40 g a doubling of the insulin response occurred. The higher dose of GIP caused a further increase in insulin response (30-min increment, 972 +/- 191 pmol/L; compared with glucose alone, 356 +/- 100 pmol/L, P less than 0.01; and compared with low GIP, 602 +/- 247 pmol/L, P less than 0.02). The glucose increment after the 40-g i.v. dose was +9.2 mmol/L. The concentration of GIP and glucose required to produce significant potentiation of the insulin response appears to be in the pharmacologic, rather than physiologic, range.
D L Sarson; S M Wood; P C Kansal; S R Bloom
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Diabetes     Volume:  33     ISSN:  0012-1797     ISO Abbreviation:  Diabetes     Publication Date:  1984 Apr 
Date Detail:
Created Date:  1984-05-14     Completed Date:  1984-05-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372763     Medline TA:  Diabetes     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  389-93     Citation Subset:  AIM; IM    
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MeSH Terms
Blood Glucose / analysis
Dose-Response Relationship, Drug
Gastric Inhibitory Polypeptide / blood,  pharmacology*
Gastrointestinal Hormones / pharmacology*
Glucose / pharmacology
Insulin / blood*
Reg. No./Substance:
0/Blood Glucose; 0/Gastrointestinal Hormones; 11061-68-0/Insulin; 50-99-7/Glucose; 59392-49-3/Gastric Inhibitory Polypeptide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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