Document Detail

Glucose consumption and lactate production in normal and fluoride adapted LS cells.
MedLine Citation:
PMID:  610877     Owner:  NLM     Status:  MEDLINE    
The established cell line LS (mouse fibroblasts) has been adapted to grow at otherwise toxic concentrations of fluoride. Different substrains of adapted LS cells consumed less glucose and converted less of the glucose to lactate than the unadapted cells. Differences were also found in the two parameters dependent on the number of generations grown in the presence of fluoride. The more generations with fluoride, the less lactate was produced and the less glucose consumed.
J K Hongslo; R I Holland
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Cell biology international reports     Volume:  1     ISSN:  0309-1651     ISO Abbreviation:  Cell Biol. Int. Rep.     Publication Date:  1977 Jul 
Date Detail:
Created Date:  1978-06-12     Completed Date:  1978-06-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7708050     Medline TA:  Cell Biol Int Rep     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  369-74     Citation Subset:  IM    
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MeSH Terms
Cell Line
Drug Resistance
Fluorides / pharmacology*
Glucose / metabolism*
Lactates / biosynthesis*
Reg. No./Substance:
0/Fluorides; 0/Lactates; 50-99-7/Glucose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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