Document Detail

Glucose Intolerance in Patients With Cystic Fibrosis: Gender-Based Differences in Clinical Score, Pulmonary Function, Radiograph Score and Six Minute Walk Test.
MedLine Citation:
PMID:  21255491     Owner:  NLM     Status:  Publisher    
Objectives To determine the gender-specific relationships between glucose intolerance and clinical score, lung function, chest radiograph score and exercise capacity in patients with cystic fibrosis (CF). Methods The study was a cross-sectional design that included CF patients aged 10 years and older. The patients were submitted to clinical and nutritional evaluations, an oral glucose tolerance test, spirometry, a chest radiograph and a six-minute walk test (6MWT). Patients were classified as having normal glucose tolerance (NGT), impaired glucose tolerance (IGT) or CF-related diabetes mellitus (CFRD). Results The study included 88 patients (59 patients with NGT, 15 with IGT and 14 with CFRD). Clinical score, peripheral oxygen saturation (SpO₂) at rest, desaturation after the 6MWT and chest radiograph score were significantly lower in the IGT group than in the NGT group (p<0.05), but did not differ from the CFRD group (p>0.05). In female patients only, forced expiratory volume in one second (FEV₁) and forced vital capacity (FVC) were significantly lower in the IGT group than in the NGT group (p<0.05), but did not differ from the CFRD group (p>0.05). There was a significant relationship between glucose intolerance and gender when clinical score, distance walked in the 6MWT, FEV₁ and the radiograph score were combined for a multivariate analysis. Conclusion The degree of impairment of glucose tolerance was associated with poor clinical score, lower SpO₂ at rest and greater desaturation after a 6MWT, poor lung function and lower radiograph score in patients with CF. Overall, a multivariate analysis indicated poorer performance for female patients with glucose intolerance for these outcomes compared to male patients.
Bruna Ziegler; Claudine Lacerda Oliveira; Paula Maria Eidt Rovedder; Sandra Jungblut Schuh; Fernando Abreu E Silva; Paulo de Tarso Roth Dalcin
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-1-21
Journal Detail:
Title:  Respiratory care     Volume:  -     ISSN:  0020-1324     ISO Abbreviation:  -     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-1-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7510357     Medline TA:  Respir Care     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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