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Glucose or Intermittent High-Intensity Exercise in Glargine/Glulisine Users with T1DM.
MedLine Citation:
PMID:  22895370     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
INTRODUCTION: The effects of glargine/glulisine insulin regimen on exercise blood glucose (BG) and strategies to limit exercise-induced hypoglycemia are not well-documented. Intermittent high intensity exercise has been proposed to prevent hypoglycemia but its effect in participants with type 1 diabetes using glargine/glulisine is unknown. METHODS: The study used a repeated-measures design with three randomly ordered exercise conditions. Eleven participants completed 60 minutes of moderate intensity exercise at 50% VO2peak for all conditions. These conditions varied as follows: participants ingested 0 g of glucose pre-exercise (0G + MOD), 30 g of glucose pre-exercise (30G + MOD), or 0 g of glucose pre-exercise, but performed brief high intensity intervals interspersed every 2 minutes (0G + MOD/INT) during exercise. If BG fell < 4 mmol/l, a 20% dextrose solution was started to maintain BG between 4 and 5 mmol/l. RESULTS: Consuming 30 g of glucose before exercise (30G + MOD) resulted in a higher pre-exercise BG (11.7 ± 2.7 mmol/l) compared to 0 g of glucose before exercise (0G + MOD: 7.8 ± 4.0 and 0G + MOD/INT: 9.2 ± 3.5mmol/l), P < 0.05. A dextrose infusion was required in 7/11, 4/11 and 1/11 participants for 0G + MOD, 0G + MOD/INT, 30G + MOD conditions, respectively, P < 0.02. The duration and the quantity of dextrose infused were greatest in the 0G + MOD condition, moderate in the to 0G + MOD/INT condition, and minimal in the 30G + MOD condition, P < 0.01. CONCLUSION: Our results suggest that both moderate intensity exercise with a 30 g pre-exercise glucose beverage or interspersed with intermittent high intensity sprints may be safe strategies to prevent hypoglycemia in glargine/glulisine users.
Authors:
Marie-Christine Dubé; Carole Lavoie; S John Weisnagel
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-14
Journal Detail:
Title:  Medicine and science in sports and exercise     Volume:  -     ISSN:  1530-0315     ISO Abbreviation:  Med Sci Sports Exerc     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8005433     Medline TA:  Med Sci Sports Exerc     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
1Diabetes Research Unit, Université Laval Medical Center, Québec City, QC, Canada 2Molecular Endocrinology and Genomics, Université Laval Medical Center, Québec City, QC, Canada 3Department of Physical Activity Sciences, Université du Québec à Trois-Rivières, QC, Canada.
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