Document Detail

Glucose-Insulin-Potassium Does Not Reduce Myocardial Infarct Size in an Ischemic/Reperfusion Rabbit Model.
MedLine Citation:
PMID:  10608046     Owner:  NLM     Status:  Publisher    
While glucose-insulin-potassium (GIK) has been suggested to be cardioprotective, few studies have assessed its effect on anatomic myocardial infarct size in an ischemia-reperfusion protocol. Anesthetized rabbits were subjected to a 30-minute coronary artery occlusion followed by 4 hours of reperfusion. Rabbits were pretreated with a GIK infusion lasting 90 minutes or placebo. GIK infusion markedly increased serum glucose levels by over twofold, but the area of necrosis expressed as the area at risk was not reduced by GIK infusion (25%) versus control (20%). In a rabbit infarct model of ischemia/reperfusion, GIK failed to reduce myocardial in infarct size.
Bellows; Kloner
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Publication Detail:
Journal Detail:
Title:  Journal of thrombosis and thrombolysis     Volume:  5     ISSN:  1573-742X     ISO Abbreviation:  J. Thromb. Thrombolysis     Publication Date:  1998  
Date Detail:
Created Date:  1999-12-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9502018     Medline TA:  J Thromb Thrombolysis     Country:  -    
Other Details:
Languages:  ENG     Pagination:  25-27     Citation Subset:  -    
Heart Institute, Good Samaritan Hospital, Los Angeles.
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