| Glucose-Insulin-Potassium Does Not Reduce Myocardial Infarct Size in an Ischemic/Reperfusion Rabbit Model. | |
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MedLine Citation:
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PMID: 10608046 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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While glucose-insulin-potassium (GIK) has been suggested to be cardioprotective, few studies have assessed its effect on anatomic myocardial infarct size in an ischemia-reperfusion protocol. Anesthetized rabbits were subjected to a 30-minute coronary artery occlusion followed by 4 hours of reperfusion. Rabbits were pretreated with a GIK infusion lasting 90 minutes or placebo. GIK infusion markedly increased serum glucose levels by over twofold, but the area of necrosis expressed as the area at risk was not reduced by GIK infusion (25%) versus control (20%). In a rabbit infarct model of ischemia/reperfusion, GIK failed to reduce myocardial in infarct size. |
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Authors:
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Bellows; Kloner |
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Publication Detail:
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Type: JOURNAL ARTICLE |
Journal Detail:
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Title: Journal of thrombosis and thrombolysis Volume: 5 ISSN: 1573-742X ISO Abbreviation: J. Thromb. Thrombolysis Publication Date: 1998 |
Date Detail:
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Created Date: 1999-12-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9502018 Medline TA: J Thromb Thrombolysis Country: - |
Other Details:
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Languages: ENG Pagination: 25-27 Citation Subset: - |
Affiliation:
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Heart Institute, Good Samaritan Hospital, Los Angeles. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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