| Glucose Ingestion Acutely Lowers Pulsatile LH and Basal Testosterone Secretion in Men. | |
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MedLine Citation:
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PMID: 22252939 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Chronic hyperglycemia inhibits the male gonadal axis. The present analyses test the hypothesis that acute glucose ingestion also suppresses LH and testosterone (T) secretion, and blunts the LH-T dose-response function. The design comprised a prospectively randomized crossover comparison of LH and T secretion after glucose vs water ingestion in a Clinical Translational Research Center. The participants were healthy men (N=57) ages 19-78 yr with body mass index (BMI) 20-39 kg/m(2). Main outcome measures were deconvolution and LH-T dose-response analyses of 10-min data. LH-T responses were regressed on glucose, insulin, leptin, adiponectin, age, BMI and CT-estimated abdominal visceral fat (AVF). During the first 120 min after glucose ingestion, for each unit decrease in LH concentrations T concentrations decreased by 86 (27-144) ng/dL (R=0.853, P<0.001). Based upon deconvolution analysis, glucose compared with water ingestion reduced (i) basal [nonpulsatile] (P<0.001) and total (P<0.001) T secretion without affecting pulsatile T output, and (ii) pulsatile (P=0.043) but not basal LH secretion. By multivariate analysis, pulsatile LH secretion positively predicted basal T secretion after glucose ingestion (R=0.374, P=0.0042). In addition, the glucose-induced fall in pulsatile LH secretion was exacerbated by higher fasting insulin concentrations (P=0.054), and attenuated by higher adiponectin levels (P=0.0037). There were no detectable changes in the analytically estimated LH-T dose-response curves (P>0.30). In conclusion, glucose ingestion suppresses pulsatile LH and basal T secretion acutely in healthy men. Suppression is influenced by age, glucose, adiponectin and insulin concentrations. |
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Authors:
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Ali Iranmanesh; Donna Lawson; Johannes D Veldhuis |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-17 |
Journal Detail:
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Title: American journal of physiology. Endocrinology and metabolism Volume: - ISSN: 1522-1555 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100901226 Medline TA: Am J Physiol Endocrinol Metab Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1Salem Veterans Affairs Medical Center. |
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