Document Detail

Glucose-6-phosphate dehydrogenase deficiency in Chinese.
MedLine Citation:
PMID:  5697334     Owner:  NLM     Status:  MEDLINE    
In a Chinese population 1,000 full-term male neonates and a further 117 jaundiced neonates of both sexes were studied in an investigation of the frequency of deficiency of erythrocyte glucose-6-phosphate dehydrogenase (G6PD). This enzyme was found to be deficient in 3.6% of male neonates. Correlation of the results with the birthplace of the 602 mothers who were known to come from Kwangtung province showed no significant differences in the frequency of the deficiency between certain parts of the province.The deficiency of G6PD in hemizygous males is profound but it is not associated with erythrocyte acid monophosphoesterase deficiency in Chinese in Hong Kong. The G6PD deficiency accounts for 15.4% of all the 117 cases of neonatal jaundice. The relative importance of G6PD deficiency as a cause of neonatal jaundice does not differ materially in male and female mutants. Neonatal jaundice can occur in all genotypes of G6PD mutation in Chinese.
H C Lai; M P Lai; K S Leung
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of clinical pathology     Volume:  21     ISSN:  0021-9746     ISO Abbreviation:  J. Clin. Pathol.     Publication Date:  1968 Jan 
Date Detail:
Created Date:  1969-01-08     Completed Date:  1969-01-08     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0376601     Medline TA:  J Clin Pathol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  44-7     Citation Subset:  AIM; IM    
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MeSH Terms
Acid Phosphatase
Asian Continental Ancestry Group
Erythrocytes / enzymology
Glucosephosphate Dehydrogenase Deficiency / complications,  epidemiology*,  genetics
Hong Kong
Infant, Newborn*
Jaundice, Neonatal / epidemiology,  etiology
Kernicterus / etiology
Metabolic Diseases / epidemiology
Reg. No./Substance:
EC Phosphatase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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