Document Detail

Glucose-6-phosphate dehydrogenase deficiency and borderline deficiency: association with neonatal hyperbilirubinemia.
MedLine Citation:
PMID:  22459229     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To characterize the occurrence of glucose-6-phosphate dehydrogenase (G6PD) deficiency and its association with neonatal hyperbilirubinemia.
STUDY DESIGN: This study involved an evaluation of G6PD data for 2656 newborns from a universal newborn screening program.
RESULTS: Mean G6PD activity was 14.2 ± 3.3 U/g Hb. Some 2.71% of the newborns were G6PD-deficient, and 1.77% had borderline G6PD activity, with male and female predominance, respectively. G6PD deficiency was more prevalent in newborns of Sephardic Jew and Muslim Arab backgrounds. The infants with G6PD deficiency had higher bilirubin levels at the time of discharge from the nursery. Infants with low and borderline G6PD activity were more likely to require phototherapy (22.2% and 25.5%, respectively, vs 7.6% of infants with normal G6PD activity; P < .005) and to have more referrals for exacerbation of jaundice (15.3% and 14.9%, respectively, vs 6.1%; P < .005). Mean G6PD activity was higher in preterm infants born at 27-34 weeks gestational age compared with those born later (16.3 ± 1.8 U/g Hb vs 14.8 ± 2.0 U/g Hb). Based on sex distribution and theoretical genetic calculations for the rate of heterozygous females, we propose that the range of borderline G6PD activity should be 2-10 U/g Hb rather than the currently accepted range of 2-7 U/g Hb.
CONCLUSIONS: There is association between G6PD deficiency and significant neonatal hyperbilirubinemia. Increased risk is also associated with borderline G6PD activity. The suggested new range for borderline G6PD activity should enhance the identification of females at risk. G6PD activity is higher in preterm infants.
Arieh Riskin; Neta Gery; Amir Kugelman; Miri Hemo; Irina Spevak; David Bader
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Publication Detail:
Type:  Journal Article     Date:  2012-03-27
Journal Detail:
Title:  The Journal of pediatrics     Volume:  161     ISSN:  1097-6833     ISO Abbreviation:  J. Pediatr.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-07-26     Completed Date:  2012-10-02     Revised Date:  2012-10-22    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  191-6.e1     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2012 Mosby, Inc. All rights reserved.
Department of Neonatology, Bnai Zion Medical Center, Haifa, Israel.
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MeSH Terms
Glucosephosphate Dehydrogenase Deficiency / complications*,  diagnosis,  ethnology
Hyperbilirubinemia, Neonatal / ethnology,  etiology*
Infant, Newborn
Neonatal Screening
Comment In:
J Pediatr. 2012 Sep;161(3):571; author reply 571-2   [PMID:  22795224 ]
J Pediatr. 2012 Aug;161(2):179-80   [PMID:  22578581 ]

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