| Glucose and 3-O-methylglucose protection against alloxan poisoning of pancreatic alpha and beta cells. | |
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MedLine Citation:
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PMID: 332568 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Alloxan infused into the isolated perfused rat pancreas caused transient insulin secretion release. Alloxan poisoning also prevented subsequent induction of glucose-mediated unsulin release and also prevented the inhibition of glucagon release by glucose. Glucose or 3-O-methylglucose infused simultaneously with alloxan protected the alpha- and beta-cell, allowing subsequent glucose inhibition of glucagon secretion and stimulation of insulin release. The above alloxan effects were dose-related, the alpha-cell being one fourth as sensitive to alloxan as the beta-cell. The data indicate that (1) alloxan and glucose suppression of amino-acid-stimulated glucagon secretion is independent of concomitant insulin secretion; (2) alloxan, like glucose, affects alpha-and beta-cells directly, stimulating the beta-cell and inhibiting the alpha-cell; and (3) alloxan acts on a glucoreceptor system with comparable physicochemical characteristics common to both cell types. |
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Authors:
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A S Pagliara; S N Stillings; W S Zawalich; A D Williams; F M Matchinsky |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Diabetes Volume: 26 ISSN: 0012-1797 ISO Abbreviation: Diabetes Publication Date: 1977 Oct |
Date Detail:
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Created Date: 1977-11-30 Completed Date: 1977-11-30 Revised Date: 2009-10-27 |
Medline Journal Info:
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Nlm Unique ID: 0372763 Medline TA: Diabetes Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 973-9 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alloxan
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pharmacology* Animals Diabetes Mellitus, Experimental / metabolism, prevention & control* Glucagon / secretion Glucose / pharmacology* Insulin / secretion Islets of Langerhans / drug effects, metabolism* Male Methylglucosides / pharmacology* Methylglycosides / pharmacology* Pancreas / drug effects, metabolism* Rats |
| Chemical | |
Reg. No./Substance:
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0/Methylglucosides; 0/Methylglycosides; 11061-68-0/Insulin; 50-71-5/Alloxan; 50-99-7/Glucose; 9007-92-5/Glucagon |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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