Document Detail

Glucoregulation during exercise : the role of the neuroendocrine system.
MedLine Citation:
PMID:  16026171     Owner:  NLM     Status:  MEDLINE    
Under normal healthy conditions, exercise initiates simultaneous elevations in hepatic glucose production (glucose R(a)) and glucose utilisation. As a result, circulating glucose levels are maintained at a relatively constant level. This relatively simple and effective relationship between the liver and the skeletal muscle is maintained by a complex interplay of circulating and locally released neuroendocrine controllers. In large part, exercise-induced changes in the pancreatic secretion of glucagon and insulin are primarily responsible for the stimulation of glucose R(a) during moderate exercise. However, exercise imposed on an additional metabolic stress (heavy exercise and poorly controlled diabetes mellitus) can increase sympathetic drive and has been suggested for decades to play a significant role in glucoregulation. In addition, blood-borne feedback and afferent reflex mechanisms may further modulate the glucose R(a) response to exercise. This article discusses new findings from novel animal and human experiments specifically designed to examine the regulatory components of the neuroendocrine system and their influence on glucoregulation during exercise.
Robert H Coker; Michael Kjaer
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Sports medicine (Auckland, N.Z.)     Volume:  35     ISSN:  0112-1642     ISO Abbreviation:  Sports Med     Publication Date:  2005  
Date Detail:
Created Date:  2005-07-19     Completed Date:  2005-11-21     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8412297     Medline TA:  Sports Med     Country:  New Zealand    
Other Details:
Languages:  eng     Pagination:  575-83     Citation Subset:  IM    
Nutrition, Metabolism, and Exercise Laboratory, Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA.
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MeSH Terms
Blood Glucose / metabolism*
Exercise / physiology*
Glucagon / metabolism*
Insulin / metabolism*
Neurosecretory Systems / metabolism*
Grant Support
Reg. No./Substance:
0/Blood Glucose; 11061-68-0/Insulin; 9007-92-5/Glucagon

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