Document Detail

Gluconic acid production.
MedLine Citation:
PMID:  19075839     Owner:  NLM     Status:  MEDLINE    
Gluconic acid, the oxidation product of glucose, is a mild neither caustic nor corrosive, non toxic and readily biodegradable organic acid of great interest for many applications. As a multifunctional carbonic acid belonging to the bulk chemicals and due to its physiological and chemical characteristics, gluconic acid itself, its salts (e.g. alkali metal salts, in especially sodium gluconate) and the gluconolactone form have found extensively versatile uses in the chemical, pharmaceutical, food, construction and other industries. Present review article presents the comprehensive information of patent bibliography for the production of gluconic acid and compares the advantages and disadvantages of known processes. Numerous manufacturing processes are described in the international bibliography and patent literature of the last 100 years for the production of gluconic acid from glucose, including chemical and electrochemical catalysis, enzymatic biocatalysis by free or immobilized enzymes in specialized enzyme bioreactors as well as discontinuous and continuous fermentation processes using free growing or immobilized cells of various microorganisms, including bacteria, yeast-like fungi and fungi. Alternatively, new superior fermentation processes have been developed and extensively described for the continuous and discontinuous production of gluconic acid by isolated strains of yeast-like mold Aureobasidium pullulans, offering numerous advantages over the traditional discontinuous fungi processes.
Savas Anastassiadis; Igor G Morgunov
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Recent patents on biotechnology     Volume:  1     ISSN:  2212-4012     ISO Abbreviation:  Recent Pat Biotechnol     Publication Date:  2007  
Date Detail:
Created Date:  2008-12-16     Completed Date:  2009-03-25     Revised Date:  2011-11-10    
Medline Journal Info:
Nlm Unique ID:  101309942     Medline TA:  Recent Pat Biotechnol     Country:  United Arab Emirates    
Other Details:
Languages:  eng     Pagination:  167-80     Citation Subset:  IM    
Pythia Institute of Biotechnology, Research in Biotechnology Co. Vat#. 108851559, Avgi Sohos, 57002, Thessaloniki, Greece.
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MeSH Terms
Ascomycota / growth & development,  metabolism
Gluconates / chemical synthesis,  chemistry*,  metabolism
Glucose / chemistry,  metabolism
Industry / trends
Patents as Topic*
Reg. No./Substance:
0/Gluconates; 50-99-7/Glucose; 526-95-4/gluconic acid

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