Document Detail

Gluconeogenic pathway in liver and muscle glycogen synthesis after exercise.
MedLine Citation:
PMID:  3288609     Owner:  NLM     Status:  MEDLINE    
To determine whether prior exercise affects the pathways of liver and muscle glycogen synthesis, rested and postexercised rats fasted for 24 h were infused with glucose (200 iv) containing [6-3H]glucose. Hyperglycemia was exaggerated in postexercised rats, but blood lactate levels were lower than in nonexercised rats. The percent of hepatic glycogen synthesized from the indirect pathway (via gluconeogenesis) did not differ between exercised (39%) and nonexercised (36%) rats. In red muscle, glycogen was synthesized entirely by the direct pathway (uptake and phosphorylation of plasma glucose) in both groups. However, only approximately 50% of glycogen was formed via the direct pathway in white muscle of exercised and nonexercised rats. Therefore prior exercise did not alter the pathways of tissue glycogen synthesis. To further study the incorporation of gluconeogenic precursors into muscle glycogen, exercised rats were infused with either saline, lactate (100, or glucose (200, containing [6-3H]glucose and [14C(U)]lactate. Plasma glucose was elevated one- to twofold and three- to fourfold by lactate and glucose infusion, respectively. Plasma lactate levels were elevated by about threefold during both glucose and lactate infusion. Glycogen was partially synthesized via an indirect pathway in white muscle and liver of glucose- or lactate-infused rats but not in saline-infused animals. Thus participation of an indirect pathway in white skeletal muscle glycogen synthesis required prolonged elevation of plasma lactate levels produced by nutritive support.
J L Johnson; G J Bagby
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  64     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1988 Apr 
Date Detail:
Created Date:  1988-07-15     Completed Date:  1988-07-15     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1591-9     Citation Subset:  IM; S    
Department of Physiology, Louisiana State University Medical Center, New Orleans 70112.
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MeSH Terms
Blood Glucose / metabolism
Glucose / metabolism
Glycogen / biosynthesis*
Insulin / blood
Lactates / blood
Liver / metabolism*
Liver Glycogen / biosynthesis*
Muscles / metabolism*
Physical Exertion*
Rats, Inbred Strains
Reference Values
Grant Support
Reg. No./Substance:
0/Blood Glucose; 0/Insulin; 0/Lactates; 0/Liver Glycogen; 50-99-7/Glucose; 9005-79-2/Glycogen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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