| Gluconeogenesis in the liver of arthritic rats. | |
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MedLine Citation:
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PMID: 10587614 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The gluconeogenic response in the liver from rats with chronic arthritis to various substrates and the effects of glucagon were investigated. The experimental technique used was the isolated liver perfusion. Hepatic gluconeogenesis in arthritic rats was generally lower than in normal rats. The difference between normal and arthritic rats depended on the gluconeogenic substrate. In the absence of glucagon the following sequence of decreasing differences was found: alanine (-71.8 per cent) reverse similarglutamine (-71.7 per cent)>pyruvate (-60 per cent)>lactate+pyruvate (-44.9 per cent)>xylitol (n.s.=non-significant) reverse similarglycerol (n.s.). For most substrates glucagon increased hepatic gluconeogenesis in both normal and arthritic rats. The difference between normal and arthritic rats, however, tended to diminish, as revealed by the data of the following sequence: alanine (-48.9 per cent) reverse similarpyruvate (-47.6 per cent)>glutamine (-33.8 per cent)>glycerol (n.s.) reverse similarlactate+pyruvate (n.s.) reverse similarxylitol (n.s.). The causes for the reduced hepatic gluconeogenesis in arthritic rats are probably related to: (a) lower activities of key enzymes catalyzing most probably steps preceding phosphoenolpyruvate (e.g. phosphoenolpyruvate carboxykinase, pyruvate carboxylase, etc. ); (b) a reduced availability of reducing equivalents in the cytosol; (c) specific differences in the situations induced by hormones or by the individual substrates. Since glycaemia is almost normal in chronically arthritic rats, it seems that lower gluconeogenesis is actually adapted to the specific needs of these animals. |
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Authors:
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Z Fedatto Júnior; E L Ishii-Iwamoto; C B Amado; G E Vicentini; A D Panerari; A Bracht; A M Kelmer-Bracht |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Cell biochemistry and function Volume: 17 ISSN: 0263-6484 ISO Abbreviation: Cell Biochem. Funct. Publication Date: 1999 Dec |
Date Detail:
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Created Date: 2000-03-07 Completed Date: 2000-03-07 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8305874 Medline TA: Cell Biochem Funct Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 271-8 Citation Subset: IM |
Copyright Information:
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Copyright 1999 John Wiley & Sons, Ltd. |
Affiliation:
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Laboratory of Liver Metabolism, University of Maringá, 87020900 Maringá, Brazil. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alanine
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metabolism Animals Arthritis, Experimental / metabolism* Gluconeogenesis* Glucose / biosynthesis* Glutamine / metabolism Glycerol / metabolism Lactic Acid / metabolism Liver / metabolism* Male Oxygen / metabolism Pyruvic Acid / metabolism Rats Rats, Wistar Xylitol / metabolism |
| Chemical | |
Reg. No./Substance:
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127-17-3/Pyruvic Acid; 50-21-5/Lactic Acid; 50-99-7/Glucose; 56-41-7/Alanine; 56-81-5/Glycerol; 56-85-9/Glutamine; 7782-44-7/Oxygen; 87-99-0/Xylitol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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