Document Detail

Gluconeogenesis in chick embryo isolated hepatocytes.
MedLine Citation:
PMID:  6345234     Owner:  NLM     Status:  MEDLINE    
1. The effectiveness of gluconeogenic precursors in hepatocytes isolated from 18 day old chick embryos is:Lactate much much greater than pyruvate greater than alanine = glutamine greater than glycerol and other amino acids. This result is qualitatively and quantitatively similar to hepatocytes isolated after hatching. 2. In the presence of endogenous glycogenolysis, conversion of [U-14C]lactate to glucose was used to estimate gluconeogenic flux and its control by hormones. 3. Glucagon failed to stimulate lactate gluconeogenesis although simultaneously increasing glycogenolysis. Insulin had no effects on gluconeogenesis.
A J Dickson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The International journal of biochemistry     Volume:  15     ISSN:  0020-711X     ISO Abbreviation:  Int. J. Biochem.     Publication Date:  1983  
Date Detail:
Created Date:  1983-08-11     Completed Date:  1983-08-11     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0250365     Medline TA:  Int J Biochem     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  861-5     Citation Subset:  IM    
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MeSH Terms
Amino Acids / pharmacology
Chick Embryo
Glucagon / pharmacology
Gluconeogenesis / drug effects*
Insulin / pharmacology
Lactates / metabolism
Lactic Acid
Liver / cytology,  embryology,  metabolism*
Liver Glycogen / metabolism
Reg. No./Substance:
0/Amino Acids; 0/Lactates; 0/Liver Glycogen; 11061-68-0/Insulin; 50-21-5/Lactic Acid; 9007-92-5/Glucagon

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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