| Glucocorticoids. | |
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MedLine Citation:
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PMID: 22265268 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Glucocorticoids remain part of the treatment strategy in many rheumatic diseases, because of their anti-inflammatory and immunosuppressive actions. Unfortunately, their clinically desired effects are linked to adverse effects, especially at higher dosages and longer duration of treatment. In this review, we describe new insights into the mechanisms of anti-inflammatory glucocorticoid actions and provide an update on recent approaches to improve the risk/benefit ratio of glucocorticoid therapy. Improved knowledge of the immunomodulatory role of endogenous glucocorticoids has evolved, and we report on the therapeutic potential of targeting glucocorticoid pre-receptor metabolism for metabolic and inflammatory diseases. |
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Authors:
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Cornelia M Spies; Cindy Strehl; Marlies C van der Goes; Johannes W J Bijlsma; Frank Buttgereit |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Best practice & research. Clinical rheumatology Volume: 25 ISSN: 1532-1770 ISO Abbreviation: Best Pract Res Clin Rheumatol Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2012-01-23 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101121149 Medline TA: Best Pract Res Clin Rheumatol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 891-900 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin, Campus Mitte, Charitéplatz 1, 10117 Berlin, Germany. |
Export Citation:
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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