| Glucocorticoids interact with the hippocampal endocannabinoid system in impairing retrieval of contextual fear memory. | |
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MedLine Citation:
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PMID: 22331883 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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There is extensive evidence that glucocorticoid hormones impair the retrieval of memory of emotionally arousing experiences. Although it is known that glucocorticoid effects on memory retrieval impairment depend on rapid interactions with arousal-induced noradrenergic activity, the exact mechanism underlying this presumably nongenomically mediated glucocorticoid action remains to be elucidated. Here, we show that the hippocampal endocannabinoid system, a rapidly activated retrograde messenger system, is involved in mediating glucocorticoid effects on retrieval of contextual fear memory. Systemic administration of corticosterone (0.3-3 mg/kg) to male Sprague-Dawley rats 1 h before retention testing impaired the retrieval of contextual fear memory without impairing the retrieval of auditory fear memory or directly affecting the expression of freezing behavior. Importantly, a blockade of hippocampal CB1 receptors with AM251 prevented the impairing effect of corticosterone on retrieval of contextual fear memory, whereas the same impairing dose of corticosterone increased hippocampal levels of the endocannabinoid 2-arachidonoylglycerol. We also found that antagonism of hippocampal β-adrenoceptor activity with local infusions of propranolol blocked the memory retrieval impairment induced by the CB receptor agonist WIN55,212-2. Thus, these findings strongly suggest that the endocannabinoid system plays an intermediary role in regulating rapid glucocorticoid effects on noradrenergic activity in impairing memory retrieval of emotionally arousing experiences. |
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Authors:
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Piray Atsak; Daniela Hauer; Patrizia Campolongo; Gustav Schelling; James L McGaugh; Benno Roozendaal |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. Date: 2012-02-13 |
Journal Detail:
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Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 109 ISSN: 1091-6490 ISO Abbreviation: Proc. Natl. Acad. Sci. U.S.A. Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-02-29 Completed Date: 2012-05-08 Revised Date: 2012-09-27 |
Medline Journal Info:
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Nlm Unique ID: 7505876 Medline TA: Proc Natl Acad Sci U S A Country: United States |
Other Details:
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Languages: eng Pagination: 3504-9 Citation Subset: IM |
Affiliation:
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Department of Neuroscience, Section Anatomy, University Medical Center Groningen, University of Groningen, 9713 AV, Groningen, The Netherlands. pirayy@gmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acoustic Stimulation Adrenergic beta-Antagonists / pharmacology Animals Arachidonic Acids / physiology* Arousal / physiology Benzoxazines / pharmacology Conditioning, Classical / drug effects, physiology Corticosterone / administration & dosage, pharmacology Electroshock Emotions / physiology Endocannabinoids / physiology* Fear / drug effects, physiology* Freezing Reaction, Cataleptic / physiology Glucocorticoids / physiology* Glycerides / physiology* Hippocampus / drug effects, physiology* Male Memory / drug effects, physiology* Morpholines / pharmacology Naphthalenes / pharmacology Piperidines / pharmacology Propranolol / pharmacology Pyrazoles / pharmacology Rats Rats, Sprague-Dawley Receptor, Cannabinoid, CB1 / antagonists & inhibitors, physiology* Receptors, Glucocorticoid / physiology |
| Chemical | |
Reg. No./Substance:
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0/AM 251; 0/Adrenergic beta-Antagonists; 0/Arachidonic Acids; 0/Benzoxazines; 0/Endocannabinoids; 0/Glucocorticoids; 0/Glycerides; 0/Morpholines; 0/Naphthalenes; 0/Piperidines; 0/Pyrazoles; 0/Receptor, Cannabinoid, CB1; 0/Receptors, Glucocorticoid; 134959-51-6/Win 55212-2; 50-22-6/Corticosterone; 525-66-6/Propranolol; 53847-30-6/2-arachidonylglycerol |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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