Document Detail


Glucocorticoids and insulin promote the differentiation of human adipocyte precursor cells into fat cells.
MedLine Citation:
PMID:  3546356     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To study the in vitro differentiation of human adipocyte precursor cells and its regulation by hormones, primary cultures of stromal vascular cells of human adipose tissue were established. A 30- to 70-fold increase in the number of developing fat cells was achieved by the addition of cortisol or related corticosteroids in the presence of insulin. Either of the two hormones alone was ineffective. The stimulatory action of cortisol was dose dependent and occurred at physiological concentrations. The results suggest that glucocorticoids may play a role in the development of human hyperplastic obesity by stimulating the formation of adipocytes from precursor cells.
Authors:
H Hauner; P Schmid; E F Pfeiffer
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  64     ISSN:  0021-972X     ISO Abbreviation:  J. Clin. Endocrinol. Metab.     Publication Date:  1987 Apr 
Date Detail:
Created Date:  1987-04-16     Completed Date:  1987-04-16     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  832-5     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adipose Tissue / cytology*,  enzymology
Adult
Cell Differentiation / drug effects
Cells, Cultured
Female
Glucocorticoids / pharmacology
Glycerolphosphate Dehydrogenase / metabolism
Humans
Hydrocortisone / physiology*
Insulin / physiology*
Middle Aged
Chemical
Reg. No./Substance:
0/Glucocorticoids; 11061-68-0/Insulin; 50-23-7/Hydrocortisone; EC 1.1.-/Glycerolphosphate Dehydrogenase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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